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EC number: 203-694-5 | CAS number: 109-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.7.1982-26.7.1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Fully documented, non GLP Study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- No stepwise approach was adopted. Only the average weight of the test animals is given, and not the weight at the beginning and end of the test.
- Principles of method if other than guideline:
- In addition to the stated guideline, the test substance was applied to damaged skin to investigate systemic effects.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pent-1-ene
- EC Number:
- 203-694-5
- EC Name:
- Pent-1-ene
- Cas Number:
- 109-67-1
- Molecular formula:
- C5H10
- IUPAC Name:
- pent-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Pentene-1
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Lot/batch No.: not reported
- Expiration date of the lot/batch: not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Russian (Albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: 10 - 11 months
- Weight: 2.7 - 2.9 kg
- Housing: single
- Diet (e.g. ad libitum): Standardized feed for test animals ALTROMIN
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 days
- gender: female
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1°C
- Humidity (%): 50 - 60 %
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12h/12h
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observation after 1, 24, 48 and 72 hours
- Number of animals:
- 3 female animals tested
- Details on study design:
- TEST SITE
- Area of exposure:
- % coverage: 100%
- Type of wrap if used: 6.25cm2 linen piece, covered by a synthetic self-adhesive strip; subsequently the patches were covered by a bandage (acrylastic)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: 4 h
SCORING SYSTEM:
Values for erythema and eschar formation as well as oedema formation were averaged for all animals and summed up. The sum resulted from 16 averages and was divided by 8 to obtain the primary irritation index:
0.0 - 0.5: non irritating
0.6 - 3.0: slightly irritating
3.1 - 5.0: moderately irritating
5.1 - 8.0: strongly irritating
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: # 1-3; intact and scarified skin
- Time point:
- other: 1, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable as no effect
- Irritation parameter:
- edema score
- Basis:
- animal: # 1-3; intact and scarified skin
- Time point:
- other: 1, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable as no effect
- Irritant / corrosive response data:
- No erythema or oedema formation was observed on any of the test animals. Merely horny skin callus developed on the intact and scarified skin in the second observation period.
- Other effects:
- No systemic toxicity effects were observed after dermal application of the product.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No reaction on intact or scarrified skin was found. The test item 1-Pentene was not skin irritant.
- Executive summary:
In the study the test item Pentene-1 was assessed for its possible skin irritation potential.
For this purpose 0.5 ml of the test substance was applied on intact and scarrified skin of three rabbits.
The animals did not show any clinical signs during the course of the study and no cases of mortality were observed.
The skin reaction score was 0, corresponding to no erythema or oedema formation.
The test item Pentene-1 was not skin irritant.
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