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EC number: 259-910-3 | CAS number: 55934-93-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted under GLP and according to OECD guideline 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- [(butoxymethylethoxy)methylethoxy]propan-1-ol
- EC Number:
- 259-910-3
- EC Name:
- [(butoxymethylethoxy)methylethoxy]propan-1-ol
- Cas Number:
- 55934-93-5
- Molecular formula:
- C13H28O4
- IUPAC Name:
- 1-[2-(2-butoxy-1-methylethoxy)-1-methylethoxy]propan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Tripropylene glycol n-butyl ether
- Physical state: Colorless liquid
- Analytical purity: 99%
- Lot/batch No.: May 87
- Stability under test conditions: Estimated to be minimum 2 years under these conditions
- Storage condition of test material: At ambient temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH, Sulzfeld
- Age at study initiation: 9 weeks approximately
- Weight at study initiation: Males: 349 to 398 gms and Females: 241 to 254 gms
- Housing: Rats were individually housed in polycarbonate cages
- Diet (ad libitum): Rats were supplied by standard diet RMH-B, pellet diameter 10 mm from Hope Farms, Woerden, and The Netherlands
- Water (ad libitum): Tap water
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C to 23°C
- Humidity (%): 65-95%
- Air changes (per hr):
- Photoperiod: 12hrs dark /12 hrs light
IN-LIFE DATES: From: 1987-10-02 to: 1987-10-16
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Fur from upper-dorso-lateral area of each animal was clipped to expose Approximately 10% of the total body surface area
- % coverage: Approximately 10% of the total body surface area
- Type of wrap if used: Undiluted test substance was evenly spread on surgical gauze (5×5 cm and 5×3.5 cm for males and females respectively) that was fixed to aluminum foil with a drop of Vaseline. Again with a drop of Vaseline this patch was attached to flexible bandage which was applied to clipped area of trunk of each animal and fixed with adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After 25 hours of exposure, the semi-occlusive bandage was removed and discarded and the remaining test substance on the treated surface was gently removed with tissues moistened with tap water.
- Time after start of exposure: 25 hours
- Duration of exposure:
- 25 hours
- Doses:
- single dose of 2000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Cage-side observations were performed on the day of dosing (approximately once every 2 hours) and daily thereafter, with exception weekends and holidays a mortality check was performed at the end of the day.
- Frequency of weighing: Weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities occurred during exposure and 14 day exposure period.
- Clinical signs:
- other: No signs of systemic toxicity were observed during exposure and 14 day observation period.
- Gross pathology:
- Macroscopic examination at necropsy of all animals at the end of the study revealed no test substance related gross abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of this the dermal LD0 of TPnB in male and female rats was > 2000 mg/kg.
- Executive summary:
One group of Wistar rats comprising 5 males and 5 females was treated with a single dermal dose of TPnB (Tripropylene glycol n-butyl ether) colorless liquid at 2000 mg/kg body weight for 25 hours. Rats were received from Charles River Wiga GmbH, Sulzfeld and kept for acclimation period of 6 days. Rats were supplied by standard diet (ad libitum) RMH-B, pellet diameter 10 mm from Hope Farms, Woerden, and The Netherlands. Rats were provided (ad libitum) with tap water throughout the study period.
Undiluted test substance was evenly spread on surgical gauze (5×5 cm and 5×3.5 cm for males and females respectively) that was fixed to aluminum foil with a drop of Vaseline. Again with a drop of Vaseline this patch was attached to flexible bandage which was applied to clipped area of trunk of each animal and fixed with adhesive tape approximately 10% of the total body surface area.
Monitored for effects included clinical observations, body weights and gross pathology. The treated skin surface of the animals revealed no irritation. In addition, observations regarding changes of treated surface were performed following bandage removal and on 4, 7 and 14. No mortalities occurred during exposure and 14 day exposure period. No signs of systemic toxicity were observed during exposure and 14 day observation period. Weekly group mean body weight gain was normal.
All surviving animals were sacrificed by Co2 asphyxiation and subjected to necropsy. Macroscopic examination at necropsy of all animals at the end of the study revealed no test substance related gross abnormalities.
Based on the results of this the dermal LD0 of TPnB in male and female rats was > 2000 mg/kg.
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