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Diss Factsheets
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EC number: 234-147-9 | CAS number: 10563-26-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Relevant methodological deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- According to the method described by Smyth H.F. et al.: Am. Ind. Hyg. Ass. J. 23, 95-107, (1962).
This test (also called inhalation hazard test) was performed in principle as described in OECD Guideline 403.
Several groups of 3 rats per sex were exposed sequentially to the vapours, generated by bubbling 200 L/h air through a substance
column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours. The temperature chosen for volatile compound generation was
usually 20 °C and the exposure time not causing lethality was determined.
No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of
the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure.
Group-wise documentation of clinical signs was performed over the 7-day study period. The clinical signs and findings were reported in
summarized form. - GLP compliance:
- no
- Test type:
- other: Inhalation Hazard Test (IHT)
- Limit test:
- yes
Test material
- Reference substance name:
- N,N'-bis(3-aminopropyl)ethylenediamine
- EC Number:
- 234-147-9
- EC Name:
- N,N'-bis(3-aminopropyl)ethylenediamine
- Cas Number:
- 10563-26-5
- Molecular formula:
- C8H22N4
- IUPAC Name:
- (3-aminopropyl)({2-[(3-aminopropyl)amino]ethyl})amine
- Details on test material:
- - Name of test material (as cited in study report): N4-Amin
- Analytical purity: > 97 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males 230 - 307 g; females 183 - 192 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The test substance vapours were generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass
cylinder for 8 hours.
- Brief description of analytical method used:
No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually was calculated as quotient of
the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure. - Duration of exposure:
- 8 h
- Concentrations:
- The nominal concentration calculated as quotient of the amount of the test substance weight loss during exposure was 0 mg/kg bw. The vapor saturation concentration of the test substance calculated based on the vapour pressure (0.0009 hPa) at 25 °C and the molecular weight (174.3 g/mol) is equal to 0.01 mg/l.
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs
Results and discussion
- Mortality:
- No mortality was observed after 8 hours exposure.
- Clinical signs:
- other: Respiratory tract irritation.
- Body weight:
- Body weight gain was observed in course of the study.
- Gross pathology:
- No abnormalities were noted.
Any other information on results incl. tables
No mortality was observed after 8 hours exposure to a saturated atmosphere.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.