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EC number: 271-231-4 | CAS number: 68526-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report equivalent or similar to OECD guideline 403: pre-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C7-9-iso-, C8-rich
- EC Number:
- 271-231-4
- EC Name:
- Alcohols, C7-9-iso-, C8-rich
- Cas Number:
- 68526-83-0
- Molecular formula:
- CnH2n+1OH (n = 7 to 9)
- IUPAC Name:
- Branched alcohols, C7-9, C8 rich
- Details on test material:
- - Name of test material (as cited in study report): MRD-78-48
- Physical state: liquid
Constituent 1
Test animals
- Species:
- other: mouse, rat and guinea pig were tested
- Strain:
- other: Swiss-Webster mice, Sprague Dawley rats, and Hartley guinea pigs
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories
- Housing: 5 per cage
- Diet (e.g. ad libitum): Purina cubed diet ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: closed chamber
- Exposure chamber volume: 100 l
- Method of holding animals in test chamber: Plexiglass chamber
- Source and rate of air: 30 l/min
- Method of conditioning air: Dried, filtered and preheated
- System of generating particulates/aerosols: three-necked flask immersed in a heated water bath and bubbled with air
- Treatment of exhaust air: Fume hood
- Temperature, humidity, pressure in air chamber: room temp - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 6 h
- Concentrations:
- Exposure concentration was determined on a nominal basis only and was calculated by dividing the net weight of compound used during the 6 h experiment by the total air flow through the chamber during the espoure. The nominal concentration was computed to be 24 ug/l.
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: daily for 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights - Statistics:
- No data was analyzed
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.024 mg/L air (nominal)
- Exp. duration:
- 6 h
- Remarks on result:
- other: For mice, rats, and guinea pigs
- Mortality:
- 0%
- Body weight:
- The exposed animals appeared to gain weight normally during the observation period.
- Gross pathology:
- Lungs were observed to be grayish or marked by gray and red foci. There were moderate incidences of mottled livers and kidneys.
- Other findings:
- As the experiment progressed, most mice became quiet, went to sleep or were mildly sedated. Respiration in some of the rats and guinea pigs appeared to be slightly labored. All signs of depressed physiological function were resolved upon moving the animals to fresh air.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classifiable
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- This data can not be used for classification purposes.
- Executive summary:
In this study, groups of male mice, rats and guinea pigs were subjected to a whole body exposure of a nominal concentration of 24 ug/l of isooctanol as a saturated vapor for 6 hours. All animals survived the study. There were indications of depressed physiological function in all animals; indicated by sedation and labored breathing. These observations were resolved once the animals were moved into fresh air. From this study, it is concluded that the LC50 is greater than 0.024 mg/l as a 6 hour exposure.
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