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EC number: 203-612-8 | CAS number: 108-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 June 2009 to 24 September 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study was conducted and reported in accordance with international test guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- US EPA Certificate
Test material
- Reference substance name:
- Hexahydro-1,3,5-trimethyl-1,3,5-triazine
- EC Number:
- 203-612-8
- EC Name:
- Hexahydro-1,3,5-trimethyl-1,3,5-triazine
- Cas Number:
- 108-74-7
- Molecular formula:
- C6H15N3
- IUPAC Name:
- 1,3,5-trimethyl-1,3,5-triazinane
- Test material form:
- liquid
- Details on test material:
- Identity: Hexahydro-1,3,5-trimethyl-s-triazineDate Received: 26 May 2009Storage Room temperature and humidityDescription: Light gold liquidSample Preparation: The test item was used as rceived
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals were received from Covance Research Products Inc., Denver, PA on 18 March 2009. Following an acclimation period of at least five days, one health New Zealand White rabbit (female) was selected from a larger group without conscious bias.The animal was born on 29 November 2008. The pretest body weight was 3.6 kg.The animal was identified by cage notation and a uniquely numbered metal ear tag and individually housed in a suspended cage. Paper bedding was was placed beneath the cage and changed at least three times per week. Fresh PMI rabbit chow (Diet #5321) was provided daily. Water was available ad libitum. The animal room was temperature controlled, had a 12 hour light: 12 hour dark photoperiod.The temperature range of the animal room was 65.6 - 76.5 degrees farenheit and the relative humidity was 48.6 to 99.5 %.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL- Amount(s) applied (volume or weight with unit): 0.5 ml per site at 3 sites.- Concentration (if solution): 32.99 % test item in water.
- Duration of treatment / exposure:
- The dressing and test article patch covering site #1 were removed at 3 minutes postdose, over site #2 at 1 hour postdose and the torso wrappings and patch covering site #3 at 4 hours postdose.
- Observation period:
- The test sites (#1, 2 and 3) were scored for dermal irritation at 60 minutes after removal of wrappings. Site #3 (4-hour exposure) was scored at 24, 48 and 72 hours and again on days 7 and 14. Erythema and edema were scored according to the numerical Draize technique. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction. Additional signs were described.Body weight was recorded pretest, 72 hours and termination. The general health of the animal was monitored at each observation point.
- Number of animals:
- One animal was used for this study.
- Details on study design:
- Site PreparationThe day prior to the application of the test item, the dorsal area of the trunk of the animal was clipped free of hair. The dose sites were approximately 3 x 3 cm.DosingInitially, one rabbit was dosed sequentially on sites #1, 2, and 3. The test item was dosed at 0.5 ml/site and placed under a 2.5 x 2.5 cm, 4 ply surgical gauze patch. Gentle pressure was applied to aid in the distribution of the test item over the contact site. The rabbit was gently held in place and a piece of porous dressing was secured with non-irritating tape over dose site #1 (semi-occlusive) for the 3 minute exposure period. The torso was covered with a piece of porous dressing large enough to cover dose sites #2 and 3 with at least 5 cm square to spare on on all sides of the gauze patch. Porous, non-irritating tape was used to encircle the trunk of the animal.The dressing and test article patch covering site #1 was removed at 3 minutes post-dose, over site #2 at 1 hour postdose and the torso wrappings and patch covering site #3 at 4 hours postdose. All sites were gently washed with distilled water to remove residual test material.Following the 72 hour observation the severity of the scores meant that no further animals were added to the study for ethical reasons. The initial animal was extended to day 14.Observation MethodErythema and edema were scored according to the numerical Draize technique. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction. Additional signs were described.ErythemaNo erythema: 0Very slight erythema (barely perceptible): 1Well defined erythema: 2Moderate to severe erythema: 3Severe erythema (beet redness) to slight eschar formation (injuries in depth): 4EdemaNo edema: 0Very slight edema (barely perceptible): 1Slight edema (edges of area well-defined by definite raising): 2Moderate edema (raised approximately 1.0 mm): 3Severe edema (raised more than 1.0 mm, extending beyond the area of exposure): 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 3 min exposure
- Time point:
- other: 60 Minutes
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 60 minute exposure
- Time point:
- other: 60 minutes
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- other: 60 minutes
- Score:
- 2
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 24 h
- Score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 48 h
- Score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 72 h
- Score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 7 d
- Score:
- > 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: necrosis and pale areas also observed
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 14 d
- Score:
- > 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: Necrosis also observed
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 3 min exposure site
- Time point:
- other: 60 minutes
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 1 hour exposure site
- Time point:
- other: 60 minutes
- Score:
- 1
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- other: 60 minutes
- Score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 24 h
- Score:
- 2
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 48 h
- Score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 7 d
- Score:
- 0
- Reversibility:
- no data
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 4 hour exposure site
- Time point:
- 14 d
- Score:
- 0
- Reversibility:
- no data
- Irritant / corrosive response data:
- Results presented above.
- Other effects:
- No systemic effects were observed during this study. Body weight changes were normal.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Hexahydro-1,3,5-trimethyl-s-triazine is corrosive.
- Executive summary:
Objective: To determine the irritant or corrosive effects, if any, of hexahydro-1,3,5 -trimethyl-s-triazine when applied dermally. This study was conducted in accordance with OECD Guideline 404 "Acute Dermal Irritation/Corrosion".
Method synopsis: Since the test item was suspected to be a dermal irritant, one health female New Xealand White rabbit was dosed dermally. The test item (0.5 ml) was applied dermally to three intact sites for an exposure period of 3 minutes on site #1, 1 hour on site #2 and 4 hours on site #3. Erythema and edema were scored at 60 minutes after each patch removal on all three sites. Site #3 was scored again at 24, 48 and 72 hours and again on days 7 and 14. The skin was also evaluated for ulceration and necrosis or any evidence of tissue destruction at these time periods. Following the 72 hour observation, the severity of the scores resulted in no further animals being added to the study. The initial animal was extended to day 14. Body weight was recorded pretest, 72 hours and at test termination.
Summary:
3 minute exposure: There were no erythema or edema observed at 60 minutes after patch removal following the 3 minute exposure.
1 hour exposure: There was no erythema and very slight edema at 60 minutes following the 1 hour exposure.
4 hour exposure: Erythema was well defined and edema was moderate at 60 minutes following the 4 hour exposure. Erythema was moderate to severe at 24 hours and severe (with no eschar formation observed) at 48 and 72 hours. By day 7, the dose site was necrotic with pale areas and necrotic on day 14. Edema was slight at 24 hours and very slight at 48 and 72 hours. By days 7 and 14, edema was absent.
Systemic Observations: There were no abnormal physical signs noted during the observation period.
Body weight changes were normal.
Conclusion: Hexahydro-1,3,5 -trimethyl-s-triazine is corrosive.
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