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EC number: 271-802-8 | CAS number: 68608-82-2 A complex combination of hydrocarbons obtained by the alkylation of benzene with ethene. It consists primarily of ethylbiphenyls, diethylbenzenes with lesser amounts of butylbenzenes and polyethylbenzenes.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted according to GLP and sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Details on test material:
- - Name of test material (as cited in study report): Untreated DPE 75 (XZ 95510)
- Distillate containing 75% diphenylethane (DPE)
- Physical state: Clear, very pale straw-colored liquid
- Storage condition of test material: Room temperature
- Source: Dow Chemical Europe S.A.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Three New Zealand White rabbits were used for the study. The animals were individually housed in suspended metal cages in a single room maintained at a temperature of 17 to 23°C and relative humidity of 40 to 70%. Artificial lighting provided 12 -hours light and 12 hours darkness. The animals were acclimatised for at least three days before treatment and individually identified by an indelible number written on the inner surface of the ear andby cage label.
The animals were allowed free access to food (Rabbit Diet, Preston Farmers Limited, New Leake, Boston, Lincolnshire, UK) and water.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: No, the untreated eye served as the control.
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Single application
- Observation period (in vivo):
- 1, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Three New Zealand White rabbits were used for the study. The animals will be held firmly but gently until quiet. The test material was placed into the eye of each rabbit by gently pulling the lower lid away from the eyeball to form a cup. For liquids the quantity administered was 0.1
ml. The untreated eye served as a control.
Assessment of ocular irritation was made 1, 24, 48 and 72-hours after treatment using the Draize Scal . A descriptive rating and
class of irritation was obtained using a modified system described by Kay J.H. and Calandra J.C., J. Soc. Cosmet. Chem. 1962, 13 281 - 289.
If irritation was present at the 72-hour observation a further reading was made on day 7.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: Dulling of cornea surface in 2 of 3 rabbits. The 3rd rabbit was scored a 0.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 48 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 72 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 48 hour
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 72 hour
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae- Redness
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- other: Conjunctivae-Redness
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae- Redness
- Basis:
- mean
- Time point:
- other: 48 hour
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae-Redness
- Basis:
- mean
- Time point:
- other: 72 hour
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae- Chemosis
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- other: Conjunctivae-Chemosis
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae-Chemosis
- Basis:
- mean
- Time point:
- other: 48 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae-Chemosis
- Basis:
- mean
- Time point:
- other: 72 hour
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae-Discharge
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- other: Conjunctivae-Discharge
- Basis:
- mean
- Time point:
- other: 24 hour
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae-Discharge
- Basis:
- mean
- Time point:
- other: 48 hour
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- other: Conjunctivae-Discharge
- Basis:
- mean
- Time point:
- other: 72 hour
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- not specified
- Irritant / corrosive response data:
- A dulling of the normal lustre of the cornea was observed in two treated eyes at the one hour reading only. No evidence of corneal irritation was
apparent at the 24-hour reading in these two treated eyes or in the remaining treated eye throughout the study period.
No evidence. of iridial inflammation was observed in any treated eye throughout the study period.
Moderate conjunctival irritation manifested as redness and chemosis was observed in all three treated eyes at the one hour observation. This
irritation regressed and had ameliorated completely in one treated eye at the 24-hour reading, in a further treated eye at the 48-hour reading and in
the remaining treated eye at the 72-hour observation. The test material produced a maximum mean score of 8.7 and was regarded as a mild irritant (Class 4 on a 1 to 8 scale) to the rabbit eye by a modified Kay and Calandra scoring scale. - Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was classified as a mild irritant (class 4 on a 1 to 8 scale) to the rabbit eye. However according to the CLP and DSD criteria this substance is not considered to be irritant to the eyes.
- Executive summary:
Untreated DPE 75 (75% diphenyl ethane), a potential thermal oil, was provided for toxicity, testing by the Olefin Derivatives Department, DCE.
Eye irritation studies were performed with 3 New Zealand White rabbits in each case. Instillation of 0.1 m l into the eye resulted in transient corneal dulling. There was some conjunctival.irritation which had resolved 48 hours after treatment. This paterial was allocated to class 4 (on a 1-8 scale) by a modified Kay and Calandra scoring system and is considered a mild eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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