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Diss Factsheets
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EC number: 212-110-8 | CAS number: 763-32-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1968-10-14 to 1968-10-22
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment; pre-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Before OECD Guideline 405 was established in 1984, skin irritation was tested using an internal method (BASF Test); the procedure of which is similar to OECD TG 405.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- 3-methylbut-3-en-1-ol
- EC Number:
- 212-110-8
- EC Name:
- 3-methylbut-3-en-1-ol
- Cas Number:
- 763-32-6
- Molecular formula:
- C5H10O
- IUPAC Name:
- 3-methylbut-3-en-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 3-methyl-3-buten-1-ol
- Analytical purity: 99%
No further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
2 male Vienna White rabbits
- Weight at study initiation: 2.65 kg (animal #1), 2.87 kg (animal #2)
- Weight at study termination: 2.74 kg (animal #1), 2.9 kg (animal #2)
No further data
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: saline-treated adjacent eye of test animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.05 ml - Duration of treatment / exposure:
- instillation without rinsing
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
SCORING SYSTEM:
BASF scoring system, convertible to Draize system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- other: 2 animals
- Time point:
- other: 1 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- other: 2 animals
- Time point:
- 24 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- other: 2 animals
- Time point:
- other: 8 days
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- other: 2 animals
- Time point:
- other: 1h - 8 days
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- other: 2 animals
- Time point:
- other: 1h
- Score:
- ca. 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- other: 2 animals
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- other: 2 animals
- Time point:
- other: 8 days
- Score:
- ca. 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- other: 2 animals
- Time point:
- other: 1 h
- Score:
- ca. 3 - ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- other: 2 animals
- Time point:
- 24 h
- Score:
- ca. 1 - 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- other: 2 animals
- Time point:
- other: 8 days
- Score:
- ca. 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 48 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 72 h
- Remarks on result:
- not measured/tested
- Irritant / corrosive response data:
- 1-hour reading:
strong conjunctival redness, very strong edema (chemosis), strong corneal opacity, brown colouration of the mucosa
24-hour reading:
slight conjunctival redness, strong edema (chemosis), strong corneal opacity, brown colouration of the mucosa
8-day reading: strong conjunctival redness, slight edema (chemosis), moderate corneal opacity, vascularization, staphyloma
Saline control:
No signs of irritation were observed at any reading. - Other effects:
- No significant change in body weight was observed for the two animals.
Any other information on results incl. tables
Table: Findings and scores (converted to Draize system)
Reading |
Eye |
Animal No. |
Corneal opacity |
Iris |
Conjunctival redness |
Chemosis |
Other findings |
1 h |
Treated |
1 2 |
3 3 |
0 0 |
2 2 |
2 3-4 |
brown colouration of the mucosa brown colouration of the mucosa |
Control |
1 2 |
No findings |
|||||
24 h |
Treated |
1 2 |
3 3 |
0 0 |
1 1 |
1 2 |
bleeding and brown colouration of the mucosa bleeding and brown colouration of the mucosa |
Control |
1 2 |
No findings |
|||||
8 d |
Treated |
1 2 |
3 3 |
0 2 |
2 2 |
1 1 |
mucosal bleeding, vascularization, staphyloma mucosal bleeding, vascularization, staphyloma |
Control |
1 2 |
No findings |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The test substance implies the risk of serious damage to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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