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Diss Factsheets
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EC number: 205-702-2 | CAS number: 147-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effect in a limit test with 1000 mg/L test item.
Key value for chemical safety assessment
Additional information
The performed GLP main experiment did not produce suitable results. In the only treatment group of nominal 500 mg test item/L, a high turbidity occurred in the replicates containing algae. This turbidity was caused by a contamination with microorganisms which could not be inhibited performing the test under sterile conditions. Due to the turbidity and/or interfering effects with the contamination the algae growth in the only treatment group was reduced and the low inhibitions allowed in a Limit test were exceeded.
In accordance with Annex XI No. 1.2 there is sufficient weight of evidence from several independent sources of information leading to the assumption/conclusion that the substance does not cause aquatic toxicity to algae. Despite of that the described limit test was performed.
Although the main part of the above mentioned limit test did not produce reliable results the non-GLP pre-experiment indicated that no effect was caused by the test item itself up to 1000 mg test item/L. A cell count of the cell density at this concentration showed no inhibition in the cell number in comparison to the control cell density. Therefore the completed part of the study confirmed the assumption that L-proline does not cause toxicity to aquatic algae and cyanobacteria.
This is not surprising. L-proline is a naturally occurring essential amino acid which is omnipresent in nature. It is a basic metabolit and building block of all living organisms and cells and is also a nutrient for algae. Thus significant toxicity to algae can be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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