tert-butyl(6-{2-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}(4S,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetate

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Annex V C1

GLP compliance:

yes

Test solutions

Details on test solutions:

Identity and concentration of auxiliary solvent for dispersal: Test solutions were stirred for 72 hours prior to addition of the test organisms

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:

semi-static

Test conditions

Hardness:

43 mg CaCO3/L

Results and discussion

Any other information on results incl. tables

Sublethal observations / clinical signs:

LC50 values
24 hour >limit of solubility
48 hour >limit of solubility
72 hour >limit of solubility
96 hour >limit of solubility
96 hour LC100 > limit of solubility
96 hour NOEC >= limit of solubility

A 10mg/l nominal concentration was prepared by stirring for 72 hours. The analytical results indicate that the test
concentration of BEM 4522 used in this study was at, or
close to, the limit of solubility.  Measured concentrations
in the centrifuged samples were <0.03 mg/l at 0 and 96
hours.

Analysis of non-centrifuged samples gave variable results -
4.9, 1.0, 2.1 mg/l at 0h and 1.1, 2.6 and 1.1 mg/l at 96h.
No mortalities were observed.