Registration Dossier
Registration Dossier
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EC number: 249-482-6 | CAS number: 29171-20-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977, other details not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: pre-GLP study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no remarks
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- EC Number:
- 249-482-6
- EC Name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- Cas Number:
- 29171-20-8
- Molecular formula:
- C10H16O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yn-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Dehydro-linalool
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No indication
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- olive oil
- Remarks:
- emulsion
- Details on oral exposure:
- Not indicated
- Doses:
- no remarks
- No. of animals per sex per dose:
- Not indicated
- Control animals:
- not specified
- Details on study design:
- Not indicated
- Statistics:
- Not indicated
Results and discussion
- Preliminary study:
- No remarks
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 100 mg/kg bw
- Mortality:
- Deaths occurred on day 1
- Clinical signs:
- Clinical signs consisted of staggering, atony, narcosis with pain and cornea reflex not present, tremors, salivation, lacrimation, spastic movements, exsiccosis.
- Body weight:
- No indication
- Gross pathology:
- No remarks
- Other findings:
- Necropsy of pre-mature deaths consisted of dilated atrium, acute congested hyperaemia of the heart, single edemateous lungs, atonic stomach / intestines. No necropsy findings were seen in animals sacrificed scheduled.
Any other information on results incl. tables
Not relevant
Applicant's summary and conclusion
- Conclusions:
- The LD50 oral in rats was calculated to be about 3100 mg/kg bw.
- Executive summary:
Deaths occurred on day 1. Clinical signs consisted of staggering, atony, narcosis with pain and cornea reflex not present, tremors, salivation, lacrimation, spastic movements, exsiccosis. Necropsy of pre-mature deaths consisted of dilated atrium, acute congested hyperaemia of the heart, single edemateous lungs, atonic stomach / intestines. No necropsy findings were seen in animals sacrificed scheduled. The LD50 oral in rats was calculated to be about 3100 mg/kg bw.
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