Registration Dossier
Registration Dossier
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EC number: 214-730-4 | CAS number: 1191-16-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No experimental toxicokinetic data are available for prenyl acetate.
Based on its physicochemical properties, i.e. small molecular weight, LogPow and good water solubility at room temperature (MW=128.2, Log Pow = 2.0, water solubility = 4300 mg/L), prenyl acetate is considered to show a good bioavailability via the dermal and oral route. On the basis of the low vapour pressure at room temperature (vapour pressure = 260 Pa), the exposure via inhalation of prenyl acetate as a vapour is low. Oral bioavailability of prenyl acetate is qualitatively indicated by observed mortalities and clinical findings in acute oral toxicity studies in rats. Furthermore, clinical signs found after single dermal application in rabbits are indicative for bioavailability via the dermal route.
Concerning metabolism and elimination, prenyl acetate is expected to hydrolyze to prenol and acetic acid. In animals hydrolysis of aliphatic esters is catalyzed by classes of enzymes recognized as carboxylesterases or esterase. Terpenoid alcohols formed in the gastrointestinal tract are then rapidly absorbed. Following hydrolysis, metabolization by alcohol oxidation, omega-oxidation, hydration, hydrogenation and conjugation to form oxygenated polar metabolites are expected, which are then excreted.
Based on the information given above, there is no evidence for a bioaccumulative potential of prenyl acetate.
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