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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
Final report on the safety assessment of benzophenones-1, -3, -4, -5, -9, and -11
Author:
Anonymous
Year:
1983
Bibliographic source:
Journal of the American College of Toxicology, Volume 2, Number 5 (1983), page 35-77

Materials and methods

Test guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dihydroxybenzophenone
EC Number:
205-029-4
EC Name:
2,4-dihydroxybenzophenone
Cas Number:
131-56-6
Molecular formula:
C13H10O3
IUPAC Name:
4-benzoylbenzene-1,3-diol

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: TA98/100/1535/1537/1538
Metabolic activation:
with and without
Metabolic activation system:
rat S9 fraction
Test concentrations with justification for top dose:
0.1 to 500 microgram/plate
Vehicle / solvent:
DMSO

Results and discussion

Test results
Species / strain:
S. typhimurium, other: TA98/100/1535/1537/1538
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not determined
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative