Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No indication for immunotoxicity

Key value for chemical safety assessment

Effect on immunotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on immunotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on immunotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No experimental data from a immunotoxicity study are available. This endpoint is not a requirement in the relevant tonnage band of the submission item according to the REACH legislation. The submission item was checked for signs of immunosuppression during the haematological investigation in the OECD TG 407 (2008) subacute repeated dose toxicity study of Dunster & Watson (2012, Harlan Report no. 41103273). In all test animals a total and differential leucocyte count comprising the number of neutrophils, lymphocytes, monocytes, eosinophils and basophils was performed at the end of exposure (day 28) or in the recovery group animals at the end of the treatment-free period (day 42). No differences between treated and control animals were observed. Due to this experimental result, the lack of chemical structure elements associated with immunotoxicity and the absence of critical information from structurally similar compounds or handling experience the submission item can be considered non-immunotoxic.

Justification for classification or non-classification

Based on the available data, the submission item is not classified.