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Diss Factsheets
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EC number: 603-923-2 | CAS number: 135590-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Assessment of PBT/vPvB Properties - Comparison with the Criteria of Annex XIII
Persistence Assessment
Mefenpyr-diethyl is not readily biodegradable in accordance with the definition given in the OECD Guidelines for the Testing of Chemicals, but Mefenpyr-diethyl is rapidly degraded by microbial induced processes. The metabolic pathway is similar for both water/sediment systems tested. Based on the results of the studies, there is no potential for a persistence of Mefenpyr-diethyl in the aquatic environment.
Additionally, tests on aerobic and anaerobic transformation in soil show half- lives to be significantly below 120 days. The route of degradation of Mefenpyr-diethyl in aerobic soil proceeded via a fast hydrolytical step to result in half-lives of degradation to range from 1 – 3 days at 20°C and to be less than one week at 10°C. In comparison, no degradation was observed in sterilised soil.
Therefore Mefenpyr-diethyl is not persistent and does not meet the P criterion.
Bioaccumulation Assessment
Results of astudy reveal that Mefenpyr-diethyl does not show significant accumulation in aquatic organisms. Due to rapid depuration, the potential for biomagnification through the food chain is low as indicated by a flow-through bioaccumulation and metabolism study with Bluegill Sunfish (Lepomis macrochirus) with a(whole fish) of 232. Following uptake the depuration of residues in fish in clean water is fast (> 95 % in 3 days) and complete. The available information indicates that Mefenpyr-diethyl has a very low potential for bioconcentration and will not accumulate to significant levels in aquatic organisms.
Therefore Mefenpyr-diethyl does not meet the B criterion.
Toxicity Assessment
From the ecotoxicity perspective the toxicity criterion is not met for Mefenpyr-diethyl with a lowest NOEC of 0.1 mg a.s./L (fish) being clearly beyond the ecologically relevant EC or LC triggers of less than 0.01 mg/L. All data give comparable results for fish and aquatic plants.
The substance is not classified as carcinogenic, mutagenic or toxic for reproduction nor is there any evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC.
Therefore Mefenpyr-diethyl does not meet the T criterion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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