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Diss Factsheets
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EC number: 431-250-2 | CAS number: 171850-30-9 ODCQA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A non-GLP study performed to sound scientific principles with a sufficient level of detail to assess the quality of the submitted data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 g test substance was instilled into each conjunctival sac of a rabbit. One eye was washed with water after a 30 second exposure, while the other eye was washed with water after one hour. Eye reaction to the test substance was assessed over a 72 hour period following instillation.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- EC Number:
- 431-250-2
- EC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Cas Number:
- 171850-30-9
- Molecular formula:
- C10H5NO3Cl2
- IUPAC Name:
- 5,7-dichloro-4-hydroxyquinoline-3-carboxylic acid
- Details on test material:
- DCHQ-acid
Appearance: white solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No further information available on test animals and environmental conditions.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 g neat test substance
- Duration of treatment / exposure:
- One eye was washed with water after a 30 second exposure.
The other eye was washed with water after 1 hour exposure. - Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- The eye irritation test included instillation of 0.1 g of neat test substance into each conjunctival sac of a female New Zealand White rabbit that had been screened for ocular defects and irritation 24 hours prior to dosing. One eye was washed with water after a 30-second exposure, while the other eye was washed with water after one hour. Irritation, in both eyes, was assessed for a period of 72 hours following instillation of the test substance.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Very slight to slight conjunctival redness and swelling was observed in the 30 second exposure eye and very slight to moderate conjunctival response was observed in the hour exposure eye. No clinical signs indicative of systemic toxicity were observed in the animal. Irritation in both eyes was cleared by 72 hours after instillation of the test substance and the study was terminated.
- Other effects:
- The animal survived the test period.
No substantial weight change was noted over the duration of the study.
Any other information on results incl. tables
Table 1: Bodyweight in kg
Animal number |
Test day 1 |
Test day 4 |
94A3615 |
3.51 |
3.60 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Very slight to slight conjunctival redness and swelling was observed in the 30 second exposure eye and very slight to moderate conjunctival response was observed in the hour exposure eye. No clinical signs indicative of systemic toxicity were observed in the animal. Irritation in both eyes was cleared by 72 hours after instillation of the test substance.
- Executive summary:
Under the conditions of the study, very slight to slight conjunctival redness and swelling was observed in the 30 second exposure eye and very slight to moderate conjunctival response was observed in the hour exposure eye. No clinical signs indicative of systemic toxicity were observed in the animal. Irritation in both eyes was cleared by 72 hours after instillation of the test substance.
Although the reporting of the study does not include scoring of the effects observed the description of these is sufficient to conclude that classification of the substance as an eye irritant is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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