Registration Dossier
Registration Dossier
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EC number: 600-715-3 | CAS number: 106092-09-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05.10.1994 to 02.11.1994
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- checked and confirmed
- IUPAC Name:
- checked and confirmed
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Chbb:THOM
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: ultra asept syringe and stomach tube
- Vehicle:
- water
- Doses:
- 280, 400, 560, 800 amd 1100 mg/kg
- No. of animals per sex per dose:
- 280 mg/kg: 5 male
400 mg/kg: 5 male
560 mg/kg: 5 male and 5 female
800 mg/kg: 5 male and 5 female
1100 mgKg: 5 female - Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 675 - < 1 100 mg/kg bw
- Based on:
- not specified
- Mortality:
- 9 of 35 treated animals died.
- Clinical signs:
- other: Prone position, reduced motility, tachypnea, exophtalmia, ataxia, tremor, piloerection and others.
- Gross pathology:
- Congestion of lung and liver, enphysema of the lung, hemorrhages in the stomach mucosa, meteorism of the stomach and intestine, redding of the stomach mucosa and others.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- SND 855 BS Y harmful by oral application.
- Executive summary:
With an approximate LD50 675.2 mg/kg b.w. in males and > 1100 mg/kg b.w. in females after oral administration in rats the precursor 3 of SND 919 CL2 Y (SND 855 BS Y) could be classified as minortoxic.
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