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EC number: 617-350-0 | CAS number: 82543-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov - Dec 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 17 alpha-(3-Hydroxypropyl)-6 beta,7 beta;15 beta,16 beta-dimethylene-5 beta-androstane-3 beta,5,17 beta-triol
- EC Number:
- 617-350-0
- Cas Number:
- 82543-18-8
- Molecular formula:
- C24 H38 O4
- IUPAC Name:
- 17 alpha-(3-Hydroxypropyl)-6 beta,7 beta;15 beta,16 beta-dimethylene-5 beta-androstane-3 beta,5,17 beta-triol
- Test material form:
- solid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): sewage treatment plant Kläranlage Berlin Ruhleben
- Storage conditions: room temperature - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 200 mg/L
- Based on:
- ThOD/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
- Test temperature: 22 °C
- pH: The pH was 7.7 to 7.8 in the blank and the substance vessels, 9.0 to 9.4 in the reference and toxicity control vessels
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: Oxitop
- Number of culture flasks/concentration: 3
SAMPLING
- Sampling frequency: after 2, 6, 10, 14, 18, 22, 26, 29 days
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 3 vessels
- Toxicity control: yes, 1 vessel
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 9
- Sampling time:
- 29 d
- Details on results:
Degradation toxicity control: 47% on day 29 (28 days of exposure)
BOD5 / COD results
- Results with reference substance:
- Degradation reference substance: 70% on day 29 (28 days of exposure)
Any other information on results incl. tables
Biological degradation (cumulative) in percent (corrected for blank O2 consumption) of ZK 92836 (selected time points)
Days of sampling | |||||||||
Test compound | Concentration expressed in theoretical O2 demand | 2 | 6 | 10 | 14 | 18 | 22 | 26 | 29 |
ZK 92836 | 200 mg/L | 1 | 2 | 3 | 6 | 9 | 9 | 7 | 5 |
Reference (sodium acetate) | 200 mg/L | 27 | 70 | 65 | 65 | 67 | 67 | 65 | 64 |
Toxicity control (ZK 92836 + sodium acetate) | 100 mg/L + 100 mg/L | 27 | 41 | 46 | 49 | 51 | 51 | 48 | 47 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test compound ZK 92836 is not readily biodegradable under the conditions of the test.
- Executive summary:
The purpose ofthis study was to determine the ready biodegradability of Dimethylenpropanol (ZK 92836), which is an intermediate of the synthesis of Drospirenone. The study was conducted in agreement with the OECD test guideline no. 301F.
The test substance ZK 92836 was incubated in an aqueous solution including nutrients with microorganisms from a municipal sewage treatment plant for 28 days (start of treatment = day 1). The test substance ZK 92836 was incubated at a concentration of 200 mg theoretical oxygen demand (ThOD) per liter. Additionally, a reference substance (sodium acetate) was tested in a single set according to the same procedure, in order to verify the viability and activity of the degrading microorganisms. One further set was incubated with sodium acetate at 100 mg ThOD/L (reference substance) plus ZK 92836 at 100 mg ThOD/L representing a toxicity control. Furthermore, a blank control was tested in triplicate without any test or reference substance. The biological degradation of the test and reference substances was evaluated by measurement of the O2 consumption during the test period.
The test compound ZK 92836 was degraded to less than 10 % until day 29 (28 days of incubation). The reference compound sodium acetate was degraded to 70% on day 6 and did not increase until day 29 (28 days of incubation). In the toxicity control, the reference compound (sodium acetate) plus the test compound ZK 92836, was degraded to 47% on day 29 (28 days ofincubation), which reflected the degradation in the individual sets.
In accordance with the OECD, the test compound ZK 92836 is not readily biodegradable under the conditions of the test and it was not toxic to the microbes of activated sludge .
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