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EC number: 219-956-7 | CAS number: 2582-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Aminoguanidinium hydrogen carbonate is not irritating to the skin and not irritating to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline used simillar to the guideline of today.
- Qualifier:
- according to guideline
- Guideline:
- other: US Department of Agriculture (Fed Reg 38, 187, 27019, 1973)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Housing: singly
- Diet ad libitum
- Water ad libitum
standard conditions - Type of coverage:
- semiocclusive
- Preparation of test site:
- other: shorn: intact and scarificed
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the opposite site served as control
- Amount / concentration applied:
- no details given
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 4
- Details on study design:
- According to the US Department of Agriculture (Fed Reg. 38, 187, 27019, 1973).
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: avg 24, 48, 72 h
- Score:
- 0
- Remarks on result:
- other: intact or scarificed skin of rabbits
- Irritant / corrosive response data:
- No irritation effects were observed
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
Aminoguanidinium hydrogen carbonate was investigated for skin irritating property in rabbits using a guideline given by the U.S. Department of Agriculture (Fed. Reg 38, 187, 27019, 1973).
Aminoguanidinium hydrogen carbonate caused no irritation in the skin of rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline used similiar to the guidelines of today
- Qualifier:
- according to guideline
- Guideline:
- other: US Department of Health, Education and Welfare : Fed Reg 37 (83), 8535, 1972
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Housing: singly
- Diet ad libitum
- Water ad libitum
standard conditions - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- no details given
- Duration of treatment / exposure:
- 5 min or 24 hours
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 4 per exposure period
- Details on study design:
- According to the US Department of Health, Education and Welfare (Fed Reg 37 (83), 8535, 1972).
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 21 days
- Score:
- 0
- Remarks on result:
- other: exposure time 5 minutes
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 21 days
- Score:
- 0
- Remarks on result:
- other: exposure time 24 hours
- Irritant / corrosive response data:
- no irrtation are observed
- Executive summary:
- Aminoguanidinium hydrogen carbonate was investigated for eye
irritating property in rabbits using a guideline given by the US
Department of Health, Education and Welfare (Fed Reg 37 (83), 8535, 1972).
Aminoguanidinium hydrogen carbonate was not irritating to the eyes of rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
Aminoguanidinium hydrogen carbonate was investigated for skin irritating property in rabbits using a guideline given by the U.S. Department of Agriculture (Fed. Reg 38, 187, 27019, 1973).
Aminoguanidinium hydrogen carbonate caused no irritation in the skin of rabbits.
Eye irritation:
Aminoguanidinium hydrogen carbonate was investigated for eye irritating property in rabbits using a guideline given by the US Department of Health, Education and Welfare (Fed Reg 37 (83), 8535, 1972).
Aminoguanidinium hydrogen carbonate was not irritating to the eyes of rabbits.
Justification for selection of skin irritation / corrosion endpoint:
Reliable study according to scientifically accepted method.
Justification for selection of eye irritation endpoint:
Reliable study according to scientifically accepted method.
Justification for classification or non-classification
Based on the available data no classification or labelling is required.
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