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EC number: 220-971-6 | CAS number: 2950-43-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In the Activated Sludge Respiration Inhibition Test, for the test substance the EC20 (30 min) was determined as ca. 450 mg/L and the EC50 as > 1000 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 000 mg/L
Additional information
For the test substance hydroxylamine-O-sulphonic acid, one reliable study is available. The test substance hydroxylamine-O-sulphonic acid was investigated in an Activated Sludge Respiration Inhibition Test (which corresponds to OECD Guideline 209) to evaluate the toxicity to microorganisms. As inoculum activated sludge from laboratory wastewater plant treating municipal sewage was used (concentration of dry substance: 1 g/L). As an outcome, for the test substance the EC20 (30 min) was determined as ca. 450 mg/L and the EC50 (30 min) as > 1000 mg/L (nominal concentration) (BASF, 2004).
Concerning the surrogate substance, there are three tests available on the respiration inhibition of activated sludge (BASF 1979, BASF 1984, BASF 2007).
Due to insufficient documentation, the two older studies (BASF 1979, 1984) have been assessed as not reliable. However, in both tests a concentration-dependent inhibition of microbial respiration was observed starting at concentrations of 0.5 - 1 mg/L. The EC20s determined in the studies were 0.6 and 1.0 mg/L.
In another study, the inhibition of oxygen consumption by activated sludge was investigated according to OECD 209 (BASF AG 2007). Activated sludge was obtained from a municipal wastewater treatment plant, test concentrations ranged from 0.05 to 504 mg/L (nominal). After 180 minutes incubation at 20 ± 2 °C the respiration rates were recorded. An EC10 of 0.7 mg/L was determined. At 50.4 mg/L 56% inihibition was observed (EC 50), at 504 mg/L 78% inhibition.
"Bis(hydroxylammonium)sulphate is known to inhibit microbial activity, also in sewage treatment plants. Other findings (e.g. Amarger & Alexander 1968), indicate an inhibition of microbial activity due to high concentrations of hydroxylamine. However, since hydroxylamine is an intermediate in the nitrification process, in lower concentrations hydroxylamine is expected to be degraded biologically to nitrite (e.g. Jetten et. al. 1997).
Taking these findings together with the data concerning transformation of bis(hydroxylammonium)sulphate, it can be assumed that the toxicity to microorganisms is associated with high concentrations of the hydroxyl-ammonium ion or hydroxylamine. In sewage treatment plants pH is buffered to pH 8 where the hydroxyl-ammonium ion is present only in very low concentrations. In addition to that, hydroxylamine (free base) is expected to decompose rapidly due to abiotic processes. The remaining concentration is not expected to inhibit microbial activity. Hence it can be assumed that additional biological degradation occurs in the waste water treatment plant." (EU-RAR Draft 14. May 2008)
Reference:ECB (2008). EU-RAR Draft, Bis-(hydroxylammonium)sulphate, CAS: 10039 -54 -0,14.May 2008
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