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EC number: 251-882-0 | CAS number: 34206-40-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue Propyltriacetoxysilane has a molecular structure similar to butan-2-one O,O',O'',O'''-silanetetrayltetraoxime and therefore, they also have comparable values for the relevant molecular properties for abiotic degradation.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Preliminary study:
- The preliminary test on analogue propyltriacetoxysilane was not performed due to the known instability of the test item.
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- Based on the experimental results with analogue propyltriacetoxysilane and applying the read-across approach, it was determined that butan-2-one O,O',O'',O'''-silanetetrayltetraoxime hidrolyses into free butanone oxime as the main hydrolysis product and silanols with fast kinetics of polycondensation reactions.
- pH:
- 1.2
- Temp.:
- 22 °C
- DT50:
- < 0.625 min
- Remarks on result:
- other: (results obtained with analogue substance propyltriacetoxysilane)
- pH:
- 4
- Temp.:
- 22 °C
- DT50:
- < 0.625 min
- Remarks on result:
- other: (results obtained with analogue substance propyltriacetoxysilane)
- pH:
- 7
- Temp.:
- 22 °C
- DT50:
- < 0.625 min
- Remarks on result:
- other: (results obtained with analogue substance propyltriacetoxysilane)
- pH:
- 9
- Temp.:
- 22 °C
- DT50:
- < 0.625 min
- Remarks on result:
- other: (results obtained with analogue substance propyltriacetoxysilane)
- Other kinetic parameters:
- Due to the extremely fast hydrolysis reaction of analogue propyltriacetoxysilane, a detailed determination of rate constants and half-life times was technically not possible.
- Details on results:
- Based on experimental results obtained with analogue propyltriacetoxysilane where hydrolysis was finished at least 150 seconds after the initial contact of the test item with water and the maximum half life time of test item was determined to be 37.5 seconds at pH 1.2, 4, 7 and 9, the read-across approach was applied and butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically unstable, with a fast hydrolysis and low half-life regardless of pH.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from experimental results on analogue propyltriacetoxysilane, butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically unstable, with a fast hydrolysis (very low half-life time) into butanone oxime and silanols regardless of pH.
- Executive summary:
The abiotic degradation of analogue substance propyltriacetoxysilane was performed according to OECD Guideline 111. The stepwise hydrolysis with formation of acetic acid as the main hydrolysis product and the presence as well as the fast kinetics of polycondensation reactions of the forming silanols (trihydroxypropylsilane) could be observed. The hydrolysis of analogue propyltriacetoxysilane was completed at least 150 seconds at pH 1.2, 4, 7 and 9 after the initial contact of the test item with water. A minimum of four completed half life cycles were estimated for the test item in a reaction time of 150 seconds and therefore the maximum half life time of <37.5 seconds was estimated for propyltriacetoxysilane. Based on these results, the read-across approach was applied and butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be rapidly hydrolysed into butanone oxime and corresponding silanols in contact with water regardless of pH.
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue MAC3 component of the reaction mass Wasox-MMAC2, has a molecular structure similar tobutan-2-one O,O',O'',O'''-silanetetrayltetraoxime and therefore, they also have comparable values for the relevant molecular properties for abiotic degradation.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- no
- Preliminary study:
- Based on read-across approach from analogue substance MAC3 (component of reaction mass Wasox-MMAC2), the preliminary test indicated that the half-life was shorter than 1 hour at 25 °C and at pH 4, pH 7 and pH 9. Therefore, it was considered to be easily hydrolysable and no main test was performed, according to the guideline.
- Test performance:
- Based on read-across approach from analogue substance MAC3 (component of reaction mass Wasox-MMAC2), the concentration was determined at the earliest possible time, i.e. 0.75 h after the start of the dissolution. Later sampling times was not required as the concentrations was already below the limit of quantification at 0.75 h.
- Transformation products:
- no
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- > 1 h-1
- DT50:
- < 1 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: (results based on analogue substance Propan-2-one-O,O',O''-(methylsilantriyl)trioxime)
- Other kinetic parameters:
- Based on read-across approach from analogue substance, no kinetic of the hydrolysis could be determined because of the slow dissolution of the test substance and the fast hydrolysis.
- Details on results:
- Based on read-across from experimental results with analogue substance MAC3 (component of reaction mass Wasox-MMAC2), the test item butan-2-one O,O',O'',O'''-silanetetrayltetraoxime is determined to hydrolyse in less than 1 hour at 25 ºC.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from experimental results obtained with analogue MAC3, butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a low half-life.
- Executive summary:
Based on the experimental results obtained with analogue substance MAC3 (half-life <1 hour at pH 4, 7 and 9 at 25 ºC), the read-across approach was applied and butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a low half-life.
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The analogue VAC3 component of the reaction mass Wasox-VMAC2, has a molecular structure similar to butan-2-one O,O',O'',O'''-silanetetrayltetraoxime and therefore, they also have comparable values for the relevant molecular properties for abiotic degradation.
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- no
- Preliminary study:
- Based on read-across approach from analogue substance VAC3 (component of reaction mass Wasox-VMAC2), the preliminary test indicated that the half-life was shorter than 1 hour at 25 °C and at pH 4, pH 7 and pH 9. Therefore, it was considered to be easily hydrolysable and no main test was performed, according to the guideline.
- Test performance:
- Based on read-across approach from analogue substance VAC3 (component of reaction mass Wasox-VMAC2), the concentration was determined at the earliest possible time, i.e. 0.75 h after the start of the dissolution. Later sampling times was not required as the concentrations was already below the limit of quantification at 0.75 h.
- Transformation products:
- no
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- > 1 h-1
- DT50:
- < 1 h
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: (results based on analogue substance acetone O,O',O''-(vinylsilanetriyl)oxime)
- Other kinetic parameters:
- Based on read-across approach from analogue substance, no kinetic of the hydrolysis could be determined because of the slow dissolution of the test substance and the fast hydrolysis.
- Details on results:
- Based on read-across from experimental results with analogue substance VAC3 (component of reaction mass Wasox-VMAC2), the test item butan-2-one O,O',O'',O'''-silanetetrayltetraoxime is determined to hydrolyse in less than 1 hour at 25 ºC.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- Based on the read-across approach from experimental results obtained with analogue VAC3, butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a low half-life.
- Executive summary:
Based on the experimental results obtained with analogue substance VAC3 (half-life <1 hour at pH 4, 7 and 9 at 25 ºC), the read-across approach was applied and butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a low half-life.
Referenceopen allclose all
Description of key information
Weight of evidence: Read-across approach from analogue VAC3 (OECD 111 and GLP): Butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a very low half-life.
Weight of evidence: Read-across approach from analogue MAC3 (OECD 111 and GLP): Butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a very low half-life.
Weight of evidence: Read-across approach from analogue propyltriacetoxysilane (OECD 111 and GLP): Butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically unstable, with a fast hydrolysis (very low half-life time) into butanone oxime and silanols regardless of pH.
Key value for chemical safety assessment
Additional information
Read-across approach from experimental results on analogue substance VAC3:
Weight of evidence: Based on the experimental results obtained with analogue substance VAC3 in a study performed according to OECD 111 and GLP (half-life <1 hour at pH 4, 7 and 9 at 25 ºC), the read-across approach was applied and butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a low half-life.
Read-across approach from experimental results on analogue substance MAC3:
Weight of evidence: Based on the experimental results obtained with analogue substance MAC3 in a study performed according to OECD 111 and GLP (half-life <1 hour at pH 4, 7 and 9 at 25 ºC), the read-across approach was applied and butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically instable with a low half-life.
Read-across approach from experimental results on analogue substance propyltriacetoxysilane:
Weight of evidence: Based on the read-across approach from experimental results obtained in a study performed in accordance with OECD 111 and GLP on analogue propyltriacetoxysilane (half-life <37.5 seconds at 25 ºC regardless pH), butan-2-one O,O',O'',O'''-silanetetrayltetraoxime was determined to be hydrolytically unstable, with a fast hydrolysis (very low half-life time) into butanone oxime and silanols.
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