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EC number: 204-605-2 | CAS number: 123-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2-Methylpentanal is an irritant to skin and mucous membranes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
In an OECD guideline 404 study (BASF AG, 1990) three rabbits were treated with the undiluted test substance for 4 h using semiocclusive conditions. The animals were observed for 15 days and skin changes were recorded. The test substance caused well-defined edema and moderate erythema 24, 48 and 72 hours after application, which were fully reversible within 15 days. In all animals scaling was observed at the end of the observation period (first noticed on day 8). Based on the results, the test substance was identified as an irritant.
This result is supported by the outcome of an older skin irritation test (BASF AG, 1977) where the test substance – applied occlusively on the skin of 2 rabbits for 1, 5, 15 min or 20 hrs – induced erythema and edema of grade 3 at the 24 h reading. At the next reading (after 8 days) these skin reactions had disappeared but desquamation was present in both animals.
Eye irritation
In an OECD guideline 405 study (BASF AG, 1990) the right eyes of three rabbits were treated with 0.1 mL of the test substance. The untreated left eyes served as control. The animals were observed for 16 days and eye changes were recorded at 24, 48, 72 hrs and at 8 and 16 days. The application of the test substance caused distinct reddening and edema formation , well-defined (conjunctivae score / chemosis score) and moderate (iris score/cornea score) eye reactions were observed within 24 - 72 hours after application, which were fully reversible within 16 days (reddening) or within 8 days.
In an earlier study (BASF AG, 1977) 50 µL of the test substance was applied to the eye of two rabbits and eye reactions were recorded 1 h and 24 hrs after test item instillation and at the end of the 8-d observation period. Also in this study the test substance was irritating to the rabbit eye.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the results obtained in the skin and eye irritation tests, 2 -Methylpentanal is classified as follows:
R38, irritating to skin (according to Directive 67/548/EEC) and H319, causes serious eye irritation, Cat. 2, and H315, causes skin irritation, Cat. 2 (according to Regulation 1272/2008/EC).
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