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Diss Factsheets
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EC number: 700-136-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 21 - March 09, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented study compliant with TG guideline and conducted under GLP in recognized contract research organization.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Principles of method if other than guideline:
- Since the test substance is a salt mixture, the flask-shaking method, HPLC method and calculation method are not applicable. Based on this, it was decided to use the estimation method for the determination of the Pow. The solubility of the test substance in n-octanol and in water was determined. The quotient of the n-octanol solubility and the water solubility is an estimation of the Pow.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: estimation method
- Partition coefficient type:
- octanol-water
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 0.009
- Temp.:
- 20 °C
- Type:
- log Pow
- Partition coefficient:
- -2.04
- Temp.:
- 20 °C
- Details on results:
- Increasing concentrations of dissolved test substance in octanol were observed in the 24, 48 and 72 hour test samples (see Table 1). In order to determine the maximum solubility, the stirring period was extended to 96, 120, 144 and 168 hours (see Table 2).
The maximum difference (MD) of the mean concentrations determined in the 96, 120, 144 and 168 hour test samples was> 15%. The 144 hour and 168 hour measurements were significantly higher than the 96 and 120 hour measurements, respectively. A plateau, i.e. maximum solubility, has been reached after 120 hours. Since the measured octanol concentrations after 144 and 168 hours of stirring were significantly higher than the concentrations measured at earlier sampling points, the samples were visually interpreted after overnight standing: the 120 hour samples was still a clear solution whereas the 144 hour and 168 hour samples had turned turbid, indicating precipitation of test substance. An explanation for this finding cannot be given. The results of the 144 hour and 168 hour samples were considered not reliable and therefore not used in any further calculations.
According to the guidelines, the octanol solubility of the test substance is given as the mean value of the mean analysed concentrations.
No test substance was detected in the pre-treated samples from the blank octanol mixture.
Any other information on results incl. tables
Table 1 Main study - n-octanol solubility of the test substance
Stirring time |
Analysed concentration |
||
|
Individual |
Mean¹ |
MD |
[hours] |
[g/l] |
[g/l] |
[%] |
24 |
4.49 |
5.70 |
49.6 |
48 |
5.51 |
|
|
72 |
7.46 |
|
|
¹ Mean of the concentrations obtained at all stirring times.
Table 2 Main study - n-octanol solubility of the test substance
after extended stirring
Stirring time |
Analysed concentration |
||
|
Individual |
Mean¹ |
MD |
[hours] |
[g/l] |
[g/l] |
[%] |
96 |
9.03 |
9.07 |
0.9 |
120 |
9.11 |
|
|
144 |
21.0 |
|
|
168 |
20.6 |
|
|
¹ Mean of the concentrations obtained at96 and 120 hours.
Applicant's summary and conclusion
- Conclusions:
- For classification purposes:: logPow <3
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