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Diss Factsheets
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EC number: 206-768-5 | CAS number: 373-61-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
Test material
- Reference substance name:
- Dihydrogen bis(acetato-O)difluoroborate(1-)
- EC Number:
- 206-768-5
- EC Name:
- Dihydrogen bis(acetato-O)difluoroborate(1-)
- Cas Number:
- 373-61-5
- Molecular formula:
- BF3 x (CH3COOH)2
- IUPAC Name:
- bis(acetic acid); trifluoroborane
- Details on test material:
- Name of test substance used in the study report: Borfluorid-Essigsaeure (40%)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animal identification: Ear tattoo
The animals were housed in fully air-conditioned rooms; the central air conditioning guaranteed a range of 20-24°C for temperature and of 30-70% for relative humidity. The day/night rhythm was 12 hours light and 12 hours dark. The animals were held (single housing) in stainless steel wire mesh cages (floor area: 3000 cm2). A standard laboratory diet and tap water were used.
The acclimatization period was at least one week. Weight determination was done shortly before application of the test substance.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: the fur was removed by clipping the dorsal of the trunk of the animals
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 3 min and 1 hour
- Observation period:
- 48 h, 72 h, 15 d
- Number of animals:
- 3 animals (3 min application); 1 animal (1 h application)
- Details on study design:
- The test substance was applied in a single dose to the intact untreated skin. The test patch was secured in position with a semiocclusive dressning. The test substance was removed at the end of the exposure period with Lutrol(R) and Lutrol(R)/water (1:1).
The test patch (2.5 x 2.5 cm) was moistened with a dose of 0.5 ml of the unchanged liquid test substance.
Application site: upper third of the back or flanks
Readings were done after 1 h, 24 h, 48 h, 72 h, 8 d and 15 d after removal of the patch.
General observations: A check was made twice each working day and once on weekends and on public holidays for general observations and for any dead or moribund animal.
Additional investigation: Because the visual assessment of the skin did not allow a statement with regard to the depth of necrotic changes (full-thickness necrosis), a cross incision of the treated skin has been performed after the animal was killed at study termination. Additionally histopathological examination has been performed in one animal.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 2.8
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: 3-min exposure
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 1-h exposure
- Irritant / corrosive response data:
- 3 minutes exposure: A mean value for erythema could not be calculatead, because in one animal visual necrosis was observed 24 hours after removal of the patch. Thus, the observation period for this rabbit was terminated after 72 hours. The macroscopic lesion of the skin was assessed by pathological examination, which revealed superficial necrosis.
The skin findings (such as erythema and edema) were reversible in one animal within 15 days, while erythema was still present in another animal at study termination.
1 hour exposure: Visual necrosis was observed in the animal after removal of the patch. Due to severe corrosion, the observation peroid was terminated after 48 hours. The macroscopic lesion of the skin was assessed by histopathological examination, which revealed severe necrosis from the coagulation type (full-thickness necrosis).
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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