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EC number: 603-931-6 | CAS number: 135800-37-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1998-06-29 to 1998-07-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study in accordance with generally accepted scientific standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- The test substances was applied at concentrations of 25%, 50% and 100% to 20 healthy volunteers in an occlusive patch test for 24 h. Texapon N25 (1%), SDS (0.5%), Aqua dest. and Paraffin perliquid were used as controls. The volunteers were subsequently investigated for skin irritation for up to 72 h after exposition.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Fatty acids, C8-16(even numbered), 2-ethylhexyl esters
- EC Number:
- 603-931-6
- Cas Number:
- 135800-37-2
- Molecular formula:
- C16H32O2 to C24H48O2
- IUPAC Name:
- Fatty acids, C8-16(even numbered), 2-ethylhexyl esters
- Details on test material:
- - Name of test material (as cited in study report): 2-Ethyl-hexylester with fatty acids C8/14
- Analytical purity: no data
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 20
- Sex: male and female
- Age: between 21 and 56 years (Mean 32.95 y) - Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- concentrations of 25%, 50% and 100% under occlusive conditions for 24 h.
- Medical treatment:
- No
Results and discussion
- Clinical signs:
- The test substance caused no effects at concentrations of 25% and 50%. The undiluted (100%) substance mainly resulted in light and transient erythema. Only one well-defined erythema and 3 cases of edema were detected.
The positive controls resulted in slight to strong erythema and slight edema formation (SDS and Texapon) in 6 and 17 volunteers, respectively, supporting the sensitivity and reliability of the test method. - Results of examinations:
- The test substance was considered to possess very good skin compatibility at 25% and 50% dilutions and good skin compatibility as undiluted substance.
- Effectivity of medical treatment:
- Not applicable
- Outcome of incidence:
- Not applicable
Any other information on results incl. tables
Number of reactions for the parameters erythema, edema desquamation and fissures differentiated according to the strength.
Substance |
Without reaction |
Erythema |
Edema |
Desquamation |
Fissures |
|||||||||||
1 |
2 |
3 |
4 |
1 |
2 |
3 |
4 |
1 |
2 |
3 |
4 |
1 |
2 |
3 |
||
Test substance (25%) |
20/20 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Test substance (50%) |
20/20 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Test substance (100%) |
13/20 |
13 |
3 |
- |
- |
- |
- |
- |
- |
1 |
- |
- |
- |
- |
- |
- |
Parrafin perliquid |
19/20 |
1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Phys. NaCl |
18/20 |
4 |
- |
- |
- |
1 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
Aqua demi. |
18/20 |
3 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
SDS (0.5%) |
14/20 |
26 |
15 |
2 |
- |
12 |
- |
- |
- |
3 |
- |
- |
- |
- |
- |
- |
Texapon N25 1% |
3/20 |
31 |
10 |
- |
- |
15 |
- |
- |
- |
- |
- |
- |
- |
- |
- |
- |
1: Slight reaction
2: Medium reaction
3: Strong reaction
4: Very strong reaction
-: No reaction
Reactions for the parameters erythema, edema desquamation and fissures added up.
Substance |
Erythema (total/mean) |
Edema (total/mean) |
Desquamation (total/mean) |
Fissures (total/mean) |
Sum of all effects (total/mean) |
Test substance (25%) |
0/0 |
0/0 |
0/0 |
0/0 |
0/0 |
Test substance (50%) |
0/0 |
0/0 |
0/0 |
0/0 |
0/0 |
Test substance (100%) |
19/0.95 |
1/0.05 |
0/0 |
0/0 |
20/1 |
Parrafin perliquid |
1/0.05 |
0/0 |
0/0 |
0/0 |
1/0.05 |
Phys. NaCl |
4/0.2 |
0/0 |
1/0.05 |
0/0 |
5/0.25 |
Aqua demi. |
3/0.15 |
0/0 |
0/0 |
0/0 |
3/0.15 |
SDS (0.5%) |
62/3.1 |
3/0.15 |
12/0.6 |
0/0 |
77/3.85 |
Texapon N25 1% |
51/2.55 |
0/0 |
15/0.75 |
0/0 |
66/3.3 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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