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EC number: 420-670-1 | CAS number: 37443-42-8 METHFAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2 july 1990 to 23 July 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to international guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl tetrahydro-2-furancarboxylate
- EC Number:
- 420-670-1
- EC Name:
- Methyl tetrahydro-2-furancarboxylate
- Cas Number:
- 37443-42-8
- Molecular formula:
- C6H10O3
- IUPAC Name:
- methyl oxolane-3-carboxylate
- Test material form:
- other: liquid
- Details on test material:
- Identification: Methyl Tetrahydrofuroate (METHFAT)
Source QO Chemicals, Inc. 2801 Kent avenue P.O. Box 2500 West Lafeyette , Indiana 47906
Date received: February 23, 1990
Lot number: PP17-9J29
Purity: Assume 100% for acute testing
Physical description: Clear colorless liquid
Storage conditions: sealed container at room temperature
Test material preparation:
A sufficient amount of neat test material waas transferred from its original container to a labeled vial that was covered and transported to the animal room for dosing. The vial contained a stir bar and was maintained on a magnetic stir plate prior to dispensation and throughout the dosing procedure.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Number on study: Four males and two females
Body weight range: 2642 to 3675 grams at study initiation
Age at Start of Study Young adult
Method of identification: Eartag
Housing: Individual suspended mesh-bottom cages. The animals were maintained by the animal husbandry staff of WIL Research Laboratories, Inc. in accordance with standard operating procedures.
Quarantine: The animals were acclimated to laboratory conditions for a minimum of 6 days prior to study initiation.
Food and water: Purina Certified Rabbit Chow # 5322 and tap water from on-site wells. Analysis of feed is performed and provided by the manufacturer. Water is analyzed twice yearly in accordance with S.O.P. No. A-020.
Environmental conditions: Animal room with controlled temperature (65-74°F), humidity (54-80%) and light (12 hours light/12 hours dark). There were approximately 10 fresh air changes per hour.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- The dose was 0.1 ml/right eye.
- Duration of treatment / exposure:
- Single exposure
- Observation period (in vivo):
- 72 hours and 21 days if irritation persisted.
- Number of animals or in vitro replicates:
- There was one group of six rabbits that received a single unwashed exposure
- Details on study design:
- Route and rationale of test material administration:
Direct conjunctival instillation. This route of administration is standard for assessment of local ocular irritative potential.
Method of test material administration
The test material was placed directly into the cupped lower conjunctival sac of each rabbit's right (test) eye. The eyelids were held closed for approximately one second after instillation. Left eyes were manipulated in an identical manner to simulate the dosing of the right eyes.
Mortality:
The rabbits were observed twice daily for mortality for the duration of the study.
Ocular observation
Both eyes of all rabbits were examined for ocular abnormalities prior to study initiation. The pre-initiation examination included the use of sodium fluorescein and ultraviolet light for detection of corneal abnormalities. Only rabbits with no pre-existing ocular abnormalities were assigned to study.
Both eyes of all rabbits were examined macroscopically for ocular irritation using a hand-held penlight in accordance with the method of Draize at approximately one, 24, 48 and 72 hours after dosing and at 4,7, 14 and 21 days if irritation persisted. In addition, both eyes of all rabbits were further examined at 72 hours and 7, 14 and 21 days with sodium fluorescein and ultraviolet light.
Body weights:
Body weight were obtained and recorded on study day 0 (initiation) and at the time of each rabbit's termination from the study.
Termination:
Upon termination from the study, the rabbits were sacrificed by intravenous overdose of anesthesia and discarded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- 47.2
- Max. score:
- 110
- Reversibility:
- not reversible
- Remarks:
- within 21 days
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 36
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 37.7
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 40.3
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 4 days
- Score:
- 42
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 30.5
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 14 days
- Score:
- 13.2
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 21 days
- Score:
- 14.8
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Based on the data obtained the Maximum Average Score for METHFAT was calculated to be 47.2 at 1 hour after dosing. Positive reactions were noted for all animals in all ocular structures evaluated (conjunctiva, iris, cornea). Corneal opacity precluded iridal evaluation for female 10822 on day 14 and 21. Iridal irritation on all other animals completely subsided by day 14 or earlier. Conjunctival irritation, including positive reactions on two animals, persisted through study termination for four rabbits. By the last day of observation (day 21) the treated eyes of three rabbits exhibited apparent irreversible corneal damage.
- Other effects:
- Mortality:
None of the rabbits died during the study period.
Body weights:
There were no significant changes or differences observed in body weights during the study period.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The Maximum Average Score for METHFAT was 47.2 at 1 hour. Positive conjunctival, iridal and corneal responses were noted for all treated eyes. All observable iridal irritation completely subsided by day 14 or earlier. Conjunctival irritation, including positive reactions on two animals, persisted through day 21 for four rabbits. Three rabbits had apparent irreversible corneal damage at study termination (day 21).
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