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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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Phenol, paraalkylation products with C12-rich branched olefins derived from propene oligomerisation, reaction products with sulphur monochloride and decene, reaction products with Benzoic acid, 2-hydroxy-,C14-18 alkyl dervis., polybutenyl benzenesulphonic acid, carbon dioxide and calcium hydroxide
EC number: 903-162-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.405 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 75
- Dose descriptor starting point:
- NOAEL
- Value:
- 59.8 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 105.4 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- Good quality oral study available. While no siginificant inhalation exposure anticipated, it is possible to derive systemic NOAEC for this route using default assumptions and the oral data to extrapolate, as per ECHA guidance ("Guidance on information requirements and chemical safety assessment; Chapter R.8: Characterisation of dose [concentration]-response for human health.)
- AF for dose response relationship:
- 1
- Justification:
- Adequate dosing and study information. No justification for deviating from the standard AF outlined in Ch R:8 based on the database.
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- No allometric scaling for inhalation route
- AF for other interspecies differences:
- 2.5
- Justification:
- According to Chapter R.8-Dose [Concentration]-Response Regarding Human Health, an additional assessment factor of 2.5 should be applied for remaining differences between test species and human. In cases where differences are not related to basal metabolic rate, the assessment factor should be modified. In terms of dynamics, one might assume that animals and humans will respond in the same way (p. 33). Based on the physicochemical properties, absorption is believed to be limited to such a degree that metabolic differences are not relevant for remaining differences. for more details see systemic dermal DNELs.
- AF for intraspecies differences:
- 5
- Justification:
- Standard default value for workers as indicated by the ECHA guidance document “Guidance on information requirements and chemical safety assessment; Chapter R.8: Characterisation of dose [concentration]-response for human health.
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable study, good quality database
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.199 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 300
- Dose descriptor starting point:
- NOAEL
- Value:
- 59.8 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 59.8 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
As a conservative assumption the oral and dermal absorption is considered identical and therefore no modification to the dose descriptor is neccessary.
- AF for dose response relationship:
- 1
- Justification:
- Default value in accordance with ECHA guidance- Chapter R.8
- AF for differences in duration of exposure:
- 6
- Justification:
- DNEL is based on 28 days oral study
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- DNEL is based on study conducted in rats
- AF for other interspecies differences:
- 2.5
- Justification:
- Default value in accordance with ECHA guidance- Chapter R.8
- AF for intraspecies differences:
- 5
- Justification:
- DNEL is calculated for workers
- AF for the quality of the whole database:
- 1
- Justification:
- Default value in accordance with ECHA guidance- Chapter R.8
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
In accordance with ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.8, Appendix R.8-8, DNELs for acute effects have not been derived as no acute adverse effects have been seen in any of the available studies. No inhalation data are available, inhalation DNELs for long term systemic exposure have been derived using extrapolation from the repeated dose oral study, it should however be noted that inhalation is not considered a relevant route of exposure given the physical-chemical properties of the material and its use pattern, both of which will mean exposure by the inhalation route will be negligible. A long-term dermal DNEL for systemic effects in workers of 0.33 mg/kg bw/day is proposed based on the repeated dose oral toxicity study in rats in which a NOAEL of 100 mg/kg bw/day was identified. This corrected to 59.8 mg/kg/day,as the sample used for toxicity testing contained 40.2% base oil.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 600
- Dose descriptor starting point:
- NOAEL
- Value:
- 59.8 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 59.8 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
ECHA Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.8, Appendix R.8-8 on Acute Toxicity states that a DNEL for acute toxicity is only necessary if "an acute toxicity hazard (leading to C&L) has been identified and there is a potential for high peak exposures". No acute toxicity hazard has been identified for the substance and, thus, no acute hazard classification is proposed. Consequently, in accordance with the ECHA guidance, an acute DN(M) EL is not required. Moreover, the physico-chemical properties of the substances confirm that there is negligible potential for inhalation of the substance.
- AF for dose response relationship:
- 1
- Justification:
- Adequate dosing and study information. No justification for deviating from the standard AF outlined in Ch R:8 based on the database.
- AF for differences in duration of exposure:
- 6
- Justification:
- Sub-acute to chronic exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- DNEL is based on study conducted in rats
- AF for other interspecies differences:
- 2.5
- Justification:
- Default value in accordance with ECHA guidance- Chapter R.8
- AF for intraspecies differences:
- 10
- Justification:
- DNEL is calculated for general population
- AF for the quality of the whole database:
- 1
- Justification:
- Reliable study, good quality database
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The registration material is only used in industrial settings, there are no consumer uses and therefore no potential for exposure to the general population. A long term oral DNEL has been calculated for the purposes of the man via the environment assessment in the chemical safety assessment. No long term inhalation DNEL has been calculated, as the physico-chemical properties of the registration substance (very low vapour pressure) mean that inhalation exposure to man via environment is not a relevant exposure route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.