Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-701-3 | CAS number: 1003-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Justification for read-across to 1,2 -Butenoxide:
For the determination of the sensitizing potential of n-pentenoxide-1,2, a read-across was performed to 1,2-Butenoxide, another member of the epoxide family. The only structural difference between n-Pentenoxid-1,2 and 1,2-Butenoxide is the presence of an additional CH2 -group in n-Pentenoxide-1,2. The chemical characteristics between these two substances are quite similar, with 1,2 -Butenoxide being more soluble in water (86.6 g/L vs 23 g/L water solubility) and less lipophilic (log Pow=0.68 vs 1.29) and exhibiting a higher vapor pressure (227 hPa vs 70 hPa) as compared with n-Pentenoxide-1,2. It has been shown that the toxicities of epoxides decrease from ethylenoxide to propylenoxide to 1,2 -Butenoxide, suggesting that the toxicity of this reactive group of epoxide chemicals decreases with increasing length of the carbon backbone (Fox et al, 1983; NTP report No 267, 1985).
The sensitizing potential of 1,2 -Butenoxide was analyzed in the guinea pig maximization test similar to the method described by Maguire (1973). The test material was applied undiluted. Ten guinea pigs received 4 applications of the test material within 7 days during the insult phase of testing. An additional group of 10 guinea pigs received DER* 331 epoxy resin as a 10% solution in DOWANOL DPM/ Tween 80 ( 9: 1). The epoxy resin is known to be a skin sensitizer and served as a positive control. Each insult application consisted of 0.1 ml of the test material or the positive control resin applied to a gauze square patch, placed on the back of the guinea pig, then secured and covered with adhesive tape. The first insult application was allowed to remain in place for 48 hours, then removed, and a second application of 0.1 ml was made. At the time of the third application, a total of 0.2 ml of Freund's Adjuvant was injected intradermally adjacent to the insult site. Forty-eight hours after this application, the patch was removed and a fresh patch of 0.1 ml of the material was applied. The last patch was removed 48 hours later and the animals were allowed to rest for two weeks. Each time the insult patches were removed, observations for primary irritation effects were
recorded. After a two-week rest period, both flanks of the animal were clipped and challenged with the test solution on one side. The challenge applications were not covered. Skin response at these sites was recorded at 24 and 48 hours after application.
A positive response indicative of sensitization (slight to moderate redness) was observed on 9 of 10 guinea pigs receiving DER 331. However, none of the 10 guinea pigs treated with the undiluted test material revealed signs of sensitization. Therefore, this material was not considered a potential human skin sensitizer.
Migrated from Short description of key information:
not sensitizing (Dow Chemical Company, 1984)
Justification for selection of skin sensitisation endpoint:
Negative responses were obtained in the guinea pig maximization test with 1,2-Butylene oxide
Justification for classification or non-classification
According to the Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP), classification for sensitization of n-Pentenoxide-1,2 is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.