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EC number: 206-190-3 | CAS number: 306-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6/14/88 - 6/28/88
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted in accordance to OECD guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Reference substance name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro- -
- IUPAC Name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro- -
- Details on test material:
- - Name of test material (as cited in study report): Ethane, 2,2-dichloro-1,1,1-trifluoro- (HCFC-123).
- Physical state: clear, liquid.
- Analytical purity: approximately 99.98% .
- Stability under test conditions: The test material was assumed to be stable under the conditions of administration.
- Storage condition of test material: The test material was received on 4/12/88 in a pressurized cylinder. A sample of the material was removed from the cylinder and stored in a refrigerator. Just prior to treatment, the sample was removed from the refrigerator and was stored in ice during dosing.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hare Marland, Hewitt, New Jersey
- Weight at study initiation: 2316-2617 grams
- Housing: singly in suspended, stainless steel, wire-mesh cages.
- Diet (e.g. ad libitum): Purina Certified High Fiber Rabbit Chow #5325 ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20C+/-2C
- Humidity (%): 50% +/- 10%
- Photoperiod (hrs dark / hrs light): 12-hour light/12-hour dark cycle
IN-LIFE Phase: From: 6/14/88 To: 6/28/88
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL aliquot of HCFC-123
- Duration of treatment / exposure:
- single dose: material was in place for 4 hours before removal
- Observation period:
- 6/14/88-6/28/88 (14 days, termination on day 15)
- Number of animals:
- 4 males and 2 females
- Details on study design:
- TEST SITE
- Area of exposure: from the scapular to the lumbar region of the back.
- Type of wrap if used: gauze secured by tape, then wrapped in rubber sheeting (approximately 8: x 18") for 4 hours.
EXPOSURE CONDITIONS
- Each rabbit was placed into a stock which was fitted with a piece of rubber sheeting. The rabbits remained in the stock throughout the exposure period and during that time did not have access to food or water.
POSITIVE CONTROL
- Sodium lauryl sulfate was used as a positive control with simultaneous exposure with Ethane, 2,2-dichloro-1,1,1-trifluoro test material.
- 0.5 ml aliquot, moistened with distilled water, was applied to a separate test site on the same animals.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gently washed with warm water and gently wiped dry.
- Time after start of exposure: 4 hours.
SCORING SYSTEM: Draize (see attached Table I: Draize Scoring system)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4, 24, 48, 72
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritant / corrosive response data:
- -HCFC-123 produced no dermal irritation in any of the treated rabbits throughout the study (See attached Table (2)).
-Primary irritation scores for the postive control material ranged from 5.0 to 6.0. It produced mild or moderate erythema with slight to moderate edema by 4 hours after treatment. By 48 hours, severe erythema with slight or mild edema was observed. - Other effects:
- Other dermal effects of the positive control substance included necrosis, superficial necrosis, thickening, raw areas or fissuring of the skin, eschar and epidermal scaling. Severe erythema and some dermal effects were still evident at study termination (day 15).
Any other information on results incl. tables
See attached result tables (2), (3), and (4)
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, dermal exposure to 2,2-dichloro-1,1,1-trifluoroethane in rabbits did not result in any irritation.
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