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EC number: 241-793-5 | CAS number: 17832-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline with acceptable restrictions (only 4 strains tested).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- only 4 strains tested
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4-(vinyloxy)butan-1-ol
- EC Number:
- 241-793-5
- EC Name:
- 4-(vinyloxy)butan-1-ol
- Cas Number:
- 17832-28-9
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 4-(ethenyloxy)butan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Vinylhydroxybutylether
- Physical state: colorless liquid
- Analytical purity: >99%
- Lot/batch No.: Vers. 2/91
- Expiration date of the lot/batch: not reported
- Storage condition of test material: 4-6°C
Constituent 1
Method
- Target gene:
- Salmonella typhimurium: (his-)
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254 induced rat liver S-9 mix
- Test concentrations with justification for top dose:
- 20, 100, 500, 2500 and 5000 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used:DMSO
Controls
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- other: with metabolic activation: 2-aminoanthracene; without metabolic activation: N-methyl-N'-nitro-N-nitrosoguanidine for TA100 and TA1535, 4-nitro-o-phenylendiamine for TA98, 9-aminoacridine chloride monohydrate for TA 1537
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation); preincubation
DURATION
- Preincubation period: 20 min at 37°C
- Exposure duration: 48-72 hr at 37°C
NUMBER OF REPLICATIONS: 3 - Evaluation criteria:
- - doubling of the spontaneous mutation rate (control)
- dose-response relationship
- reproducibility of the results - Statistics:
- Mean and standard deviation calculated in result tables. No further data.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Mean Revertants/ plate in Standard plate test
Dose (µg/ml) |
TA 98 |
TA 100 |
TA 1535 |
TA 1537 |
||||
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
|
0 |
28 |
41 |
115 |
116 |
18 |
23 |
8 |
13 |
20 |
31 |
42 |
101 |
128 |
16 |
18 |
10 |
12 |
100 |
38 |
38 |
108 |
129 |
15 |
14 |
8 |
9 |
500 |
32 |
52 |
118 |
114 |
17 |
15 |
8 |
10 |
2500 |
29 |
41 |
121 |
125 |
17 |
18 |
11 |
13 |
5000 |
40 |
30 |
114 |
125 |
16 |
13 |
11 |
11 |
Positive control |
787 |
982 |
1315 |
1160 |
1500 |
329 |
458 |
140 |
Mean Revertants/ plate in Pre incubation test
|
TA 98 |
TA 100 |
TA 1535 |
TA 1537 |
||||
Dose (µg/ml) |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
-S9 |
+S9 |
0 |
28 |
41 |
117 |
132 |
16 |
12 |
12 |
12 |
20 |
29 |
39 |
118 |
121 |
12 |
13 |
9 |
14 |
100 |
27 |
39 |
122 |
114 |
12 |
11 |
9 |
11 |
500 |
22 |
46 |
112 |
72 |
11 |
13 |
8 |
15 |
2500 |
25 |
49 |
108 |
92 |
13 |
13 |
9 |
13 |
5000 |
26 |
39 |
126 |
110 |
19 |
20 |
6 |
16 |
Positive control |
899 |
1583 |
2010 |
4963 |
2077 |
249 |
536 |
152 |
Applicant's summary and conclusion
- Executive summary:
This study was conducted comparable to the OECD Guideline 471 and is reliable with acceptable restrictions (missing TA102/ E. coli strain, standard plate test only, no GLP). The test substance was tested in the standard plate test and pre-incubation test with and without metabolic activation (MA) in S. typhimurium TA98, TA100, TA1535 and TA1537 at dose levels of 20 -5000 µg/plate. No increase in the number of revertants was detected in any strain with and without MA. No bacteriotoxic effect was observed. Vehicle controls and positive controls were valid.
Conclusion: According to the results of the present study, the test substance is not mutagenic in the Salmonella typhimurium reverse mutation assay under the experimental conditions chosen here.
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