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EC number: 601-327-7 | CAS number: 114772-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 15 September 1994 to 29 september 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to international guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
- EC Number:
- 601-327-7
- Cas Number:
- 114772-54-2
- Molecular formula:
- C14H10BrN
- IUPAC Name:
- 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile
- Details on test material:
- SR 48941
Batch 4SNP006
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: OFA-SD (IOPS Caw)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Each group was composed of 5 animals of the sale sex. Animals were subjected to clinical examination and selected if they were in good health. The animals were assigned manually to the experimental group and identified by tattoo according to the Standard Operating Procedures.
- Source: Iffa Credo
- Age at study initiation: approximately 5 weeks old
- Weight at study initiation: 135 to 153 grams for males and 119 to 135 grams for females.
- Housing: Rats were housed 2 or 3 of the same group to stainless steel cages (891 cm² x 18 cm).
- Diet (e.g. ad libitum):free access to UAR AO4C. Food was withdrawn 18 hours before treatment and redistributed approximatly 4 hours after gavage.
- Water (e.g. ad libitum): tap water
- Acclimation: at least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C (+/- 2°C)
- Relative Humidity (%): 40-70 %
- Air changes (per hr): air was renewed 10 to 11 times per hour without recycling.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.6% methylcellulose aqueous solution
- Doses:
- 0 and 2000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females per group
- Control animals:
- yes
- Details on study design:
- Animals were kept under observation for 15 days following administration. During this period, clinical signs and cases of mortality were recorded.
A study of body weight changes was performed by weighing the animals on the day of treatment (D1), then on D3, D8 and D15.
Post-mortem macroscopic examination was performed in the animals found dead during the study. Lethal dose values were calculated, when possible, after mortality 15 days following treatment.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality recorded
- Clinical signs:
- other: No abnormality detected
- Gross pathology:
- No abnormality detected
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dose level of 2000 mg/kg was non lethal (with LD50 > 2000 mg/kg), and did not induce adverse effects in rats of either sex.
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