Phenylacetic acid

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary database.

Data source

Reference

Reference Type:

other: secondary source

Title:

Toxicology in the animal experiment

Author:

GSBL

Year:

2018

Bibliographic source:

GSBL

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Acute inhalation toxicity study was conducted by using the given test chemical

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Phenylacetic acid

EC Number:

203-148-6

EC Name:

Phenylacetic acid

Cas Number:

103-82-2

Molecular formula:

C8H8O2

IUPAC Name:

phenylacetic acid

Test material form:

solid

Details on test material:

- Name of test material: Benzeneacetic acid
- Molecular formula: C8H8O2
- Molecular weight: 136.149 g/mole
- Smiles : c1(ccccc1)CC(O)=O
- Inchl: 1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)
- Substance type: Organic
- Physical state: solid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 7-9 weeks
- Weight at study initiation: mean 200g weight

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

not specified

Vehicle:

not specified

Details on inhalation exposure:

not specified

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

5 mg/L

No. of animals per sex per dose:

5 M and 5 W / dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: Animals were observed for mortality, clinical signs, and body weight changes.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 5 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Mortality:

No mortality was observed at 5 mg/L.

Clinical signs:

other: No clinical signs of intoxication within 14 d of follow-up.

Body weight:

No effect on body weight on the 7th and 14th day after exposure.

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

The acute inhalation toxicity dose (LC50) value was considered to be >5 mg/L (>5000 mg/m3), when male and female wistar rats were treated with the given test chemical via inhalation route by aerosoles for 4-h exposure.

Executive summary:

The acute inhalation toxicity study was conducted by using the given test chemical as per OECD Guideline 403 (Acute Inhalation Toxicity) in 10 male and female Wistar rats via inhalation route by aerosoles for 4-h exposure at the dose concentration of 5 mg/L.

Animals were observed for mortality, clinical signs, and body weight changes for 14 days. No mortality was observed at 5 mg/L. No clinical signs of intoxication within 14 d of follow-up. No effect on body weight on the 7th and 14th day after exposure.

Hence, the  acute inhalation toxicity dose (LC50) value was considered to be >5 mg/L (>5000 mg/m3), when male and female wistar rats were treated with the given test chemical via inhalation route by aerosoles for 4-h exposure.