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EC number: 225-060-7 | CAS number: 4635-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 JUNE 2007 to 16 AUGUST 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study follows international guidelines and comply with GLP. The study design is adapted to the test substance yet no certificate of analysis was provided therefore doubts remain whether the test substance is the reference substance of the current dossier. Thus the results are deemed reliable with this last restriction.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0h, 48h, 120h
- Sampling method: in duplicate
- Sampling methods for the volatile compounds, if any: No headspace was left in the vessel to stop volatilisation of the test material
- Sampling intervals/times for pH measurements: 0h, 48h, 120h
- Sampling intervals/times for sterility check: no data
- Sample storage conditions before analysis: shielded from light
- Other observation, if any (e.g.: precipitation, color change etc.): no data - Buffers:
- pH=4 - Potassium hydrogen phtalate at 0.005M
pH=7 - Disodium hydrogen orthophosphate (anhydrous) at 0.003M - Potassium dihydrogen orthophosphate (anhydrous) at 0.002M - sodium chloride at 0.002M
pH=9 - Disodium tetraborate 0.001M - Sodium chloride 0.002M
All buffers were filtered at 0.2µm - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: stoppered glass flasks.
- Sterilisation method: 0.2 µm filtration
- Lighting: prevent for samples
- Measures taken to avoid photolytic effects: no data
- Measures to exclude oxygen: solutions were subjected to ultrasonication and degassing with nitrogen to minimize dissolved oxygen content.
- Details on test procedure for unstable compounds: not applicable
- Details of traps for volatile, if any no data
- If no traps were used, is the test system closed/open: closed system with no headspace left in vessels
- Is there any indication of the test material adsorbing to the walls of the test apparatus? no
TEST MEDIUM no details
OTHER TEST CONDITIONS no details - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- 518 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- 508 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50
- Initial conc. measured:
- 485 mg/L
- Number of replicates:
- duplicate at each time interval
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- no data
- Preliminary study:
- A preliminary study at 50°C was performed. Since hydrolysis half-life was estimated to be over one year at pH = 4, pH = 7 and pH = 9, the study was terminated.
- Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- no further details
- % Recovery:
- > 95.4 - < 95.9
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 103
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 103
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Validity criteria fulfilled:
- yes
- Conclusions:
- The half-life of the test substance at 25°C is estimated to be over 1 year.
- Executive summary:
The hydrolysis as a function of pH was determined for the test substance following a GLP study according to OECD 111 guidelines. Solutions of 0.5 g/L of test substance in buffers at pH = 4, 7, and 9 were maintained at 50°C for 5 days and sampled at 0h, 48h, and 120h by gas chromatography.
At all tested pH, less than 10% of hydrolysis were measured, thus half-life of the test substance at 25°C was estimated to be over one year.
Reference
Description of key information
The half life of the substance is over 1 year at pH 4, 7 and 9.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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