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EC number: 247-728-7 | CAS number: 26479-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Endpoint summary
- Stability
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a skin irritation/corrosion study on rabbits conducted in accordance with OECD Testing Guideline 404 and under GLP, the test substance produced a primary irritation index of 0.5 and was classified as a MILD IRRITANT to rabbit skin according to the Draize classification scheme. However, the test substance did not meet the criteria for classification as an irritant or corrosive according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) or the Classification, Labelling and Packaging (CLP) Regulation (EC) No. 1272/2008. Therefore, under the conditions of this study, potassium allophonate is not considered to be irritating to the skin. In an eye irritation study on rabbits conducted in accordance with OECD Testing 405 and under GLP, no corneal or iris abnormalities were observed in the eyes of any animal at any time point. All three animals demonstrated mild conjunctival redness and discharge within 1 and 4 hours which resolved by the 24-h observation period. No fluorescein staining was present in the eyes of the animals at any time point during the study. Therefore, under the conditions of this study, potassium allophonate is not considered to be irritating to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed under GLP/OECD guideline without deficiency.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Male New Zealand White rabbits from Harlan UK Ltd, Bicester (HsdIf:NZW strain).
- Age at study initiation: 12 to 13 weeks old.
- Weight at study initiation: 2.2 to 2.5 kg
- Housing:Individually housed in cages.
- Diet (e.g. ad libitum):Global Diet 2930C (Harlan Teklad, Bicester, UK) was freely available to the animals at all times.
- Water (e.g. ad libitum):Mains water was provided, ad libitum, via cage-mounted water bottles.
- Acclimation period: 7 to 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):15 to 21 degrees C
- Humidity (%):Humidity did not fall below the limit specified in the protocol (45%).
- Air changes (per hr):15 to 20
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: From 14 February 2012 to 28 February 2012. - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):500 mg
VEHICLE
- Amount(s) applied (volume or weight with unit):none - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 15 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: A 30 x 20 mm area on the closely clipped dorsum.
- % coverage:100%
- Type of wrap if used: none
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lightly brushed clean of any solid residues and swabbed with moist cotton wool.
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Erythema & eschar Grade
No erythema 0
Very slight erythema 1
Well-defined erythema 2
Moderate erythema 3
Severe erythema (beet redness) or eschar formation preventing reading of erythema 4
Oedema Grade
No oedema 0
Very slight oedema (barely perceptible) 1
Slight oedema (edges of area well-defined by definite raising) 2
Moderate oedema (edges raised approximately 1 mm) 3
Severe oedema (raised more than 1 mm and extending beyond the dermal test site) 4
The scores for erythema and oedema at the 24 and 72 hour readings were totalled for the three test rabbits (12 values) and this total was divided by six to give the primary irritation index of the test article.
Primary Irritation Index Classification of Irritancy
0 Non irritant
>0 to 2 Mild irritant
>2 to 5 Moderate irritant
>5 to 8 Severe irritant - Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- ca. 0.5
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0.333
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: very slight erythema in one animal
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48 h
- Score:
- 0.333
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: very slight erythema in one animal
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0.667
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: well-defined erythema in one animal
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- - Very slight erythema was noted at one treated skin site at 24 and 48 hours after patch removal. Well-defined erythema was noted at this site 72 hours after patch removal with very slight erythema and fissuring present on Day 8. No evidence of skin irritation was noted at this treated skin site on Day 15.
- No evidence of skin irritation was noted at the other two treated skin sites during the observation period. - Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test article produced a primary irritation index of 0.5 and was classified as a MILD IRRITANT to rabbit skin according to the Draize classification
scheme. The test article did not meet the criteria for classification as irritant or corrosive according to the Globally Harmonized System of
Classification and Labelling of Chemicals (GHS).
Reference
Table1
Individual dermal reactions
Animal number, sex, initial body weight and final body weight |
Dermal reaction |
Observation time after removal of patches |
||||||
Imm |
1 hour |
24 hours |
48 hours |
72 hours |
7 days |
14 days |
||
4M |
Erythema/Eschar formation |
0 |
0 |
1 |
1 |
2 |
1 |
0 |
Oedema formation |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Other |
- |
- |
- |
- |
- |
FS |
- |
|
5M |
Erythema/Eschar formation |
N/A |
0 |
0 |
0 |
0 |
N/A |
N/A |
Oedema formation |
N/A |
0 |
0 |
0 |
0 |
N/A |
N/A |
|
Other |
N/A |
- |
- |
- |
- |
N/A |
N/A |
|
6M |
Erythema/Eschar formation |
N/A |
0 |
0 |
0 |
0 |
N/A |
N/A |
Oedema formation |
N/A |
0 |
0 |
0 |
0 |
N/A |
N/A |
|
Other |
N/A |
- |
- |
- |
- |
N/A |
N/A |
|
Sum of 24 and 72 hour readings (S) |
: |
3 |
||||||
Primary Irritation Index (S/6) |
: |
3/6 = 0.5 |
||||||
Classification |
: |
MILD IRRITANT |
Key:
Imm Immediately after removal of patch
FS Fissuring
N/A Not applicable
Table 2
Individual Daily and Mean Scores for Dermal Irritation Following 4 Hour
Exposure
Dermal reaction |
Observation Time |
Individual Scores � Rabbit Number and Sex |
|
||
4M |
5M |
6M |
|||
Erythema/Eschar Formation |
24 Hours |
1 |
0 |
0 |
|
48 Hours |
1 |
0 |
0 |
||
72 Hours |
2 |
0 |
0 |
||
Total |
4 |
0 |
0 |
||
Mean Score |
1.3 |
0.0 |
0.0 |
||
Oedema Formation |
24 Hours |
0 |
0 |
0 |
|
48 Hours |
0 |
0 |
0 |
||
72 Hours |
0 |
0 |
0 |
||
Total |
0 |
0 |
0 |
||
Mean Score |
0.0 |
0.0 |
0.0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to GLP/OECD guideline without deficiency.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:Male New Zealand White rabbits from Harlan UK Ltd, Bicester (HsdIf:NZW strain).
- Age at study initiation:Approximately 12 weeks old.
- Weight at study initiation:2.3 to 2.7 kg
- Housing:Rabbits were individually housed.
- Diet (e.g. ad libitum):Global Diet 2930C (Harlan Teklad, Bicester, UK), ad libitum.
- Water (e.g. ad libitum):Mains water was provided, ad libitum, via cage-mounted water bottles.
- Acclimation period: 7 to 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C):15 to 21 degrees C
- Humidity (%):Humidity did not fall below the limit specified in the protocol (45%).
- Air changes (per hr):15 to 20
- Photoperiod (hrs dark / hrs light):12/12
IN-LIFE DATES: From 19 March 2012 to 30 March 2012. - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):100 mg of powdered test article.
VEHICLE
- Amount(s) applied (volume or weight with unit):none - Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- The treated animals were examined for ocular changes approximately 30 minutes, one and four hours after treatment and on Days 2, 3 and 4 (at
approximately 24, 48 and 72 hours post treatment). - Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done):no
SCORING SYSTEM:
-The "initial sting" response was assessed and recorded immediately after instillation of the test article on Day 1.
The response was graded according to the following scheme:
Response of animal Grade Sting response
No response 0 None
A few blinks only, normal within two minutes 1 Practically none
Rabbit blinks and attempts to open eye but reflex closes it 2 Slight
Rabbit keeps eye shut and puts pressure on it, may rub eye 3 Moderate
Rabbit holds eye tightly shut, may struggle or squeal 4 Marked
Grading of Ocular Reactions
CONJUNCTIVAE
Grade
(A) Redness (refers to palpebral and bulbar conjunctivae excluding cornea and iris)
Blood vessels normal 0
Some blood vessels definitely hyperaemic (injected) 1
Diffuse, crimson colour, individual vessels not easily discernible 2
Diffuse beefy red appearance 3
(B) Chemosis (refers to lids and/or nictitating membrane)
No swelling 0
Any swelling above normal 1
Obvious swelling with partial eversion of lids 2
Swelling with lids about half-closed 3
Swelling with lids more than half-closed 4
(C) Discharge
No discharge 0
Any discharge greater than normal (not including the small amount normally present in the inner canthus of normal animals) 1
Discharge with moistening of lids and hairs just adjacent to the lids 2
Discharge with moistening of lids and hairs for a considerable area around the eye 3
TOTAL SCORE = (A + B + C) x 2 MAXIMUM TOTAL = 20
IRIS (D) Grade
Normal 0
Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia or injection (any of these or any combination thereof); iris still reacting to light (a sluggish reaction is an effect) 1
Haemorrhage, gross destruction, no reaction to light (any or all of these) 2
TOTAL SCORE = D x 5 MAXIMUM TOTAL = 10
CORNEA Grade
(E) Degree of opacity (most dense area used)
No ulceration or opacity 0
Scattered or diffuse areas of opacity (other than slight dulling of normal lustre); details of iris clearly visible 1
Easily discernible translucent areas; details of iris slightly obscured 2
Nacreous areas; no details of iris visible; size of pupil barely discernible 3
Opaque cornea; iris not discernible through opacity 4
(F) Area of cornea involved
One quarter (or less) but not zero 1
Greater than one quarter but not more than half 2
Greater than half but not more than three quarters 3
Greater than three quarters, up to whole area 4
TOTAL SCORE = (E x F) x 5 MAXIMUM TOTAL = 80
MAXIMUM TOTAL SCORE POSSIBLE = 110
TOOL USED TO ASSESS SCORE: fluorescein - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: all time points
- Score:
- 0
- Max. score:
- 80
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: all time points
- Score:
- 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 0.5 h, 1 h
- Score:
- 6.7
- Max. score:
- 20
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 4 h
- Score:
- 2
- Max. score:
- 20
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 0.5 h, 1 h
- Score:
- 6.7
- Max. score:
- 110
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- other: maximum group mean score (based on effects on the conjunctivae at 1 hour)
- Irritant / corrosive response data:
- - There were no corneal or iridial effects noted.
- Minimal to moderate conjunctival irritation was noted in all treated eyes 0.5 and 1 hour after instillation, with minimal conjunctival irritation persisting in two treated eyes 4 hours after instillation. No signs of irritation were observed at 24, 48 or 72 hours.
- The eyes of all rabbits were overtly normal by the 24 hour examination. - Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test article produced a maximum group mean score of 6.7 and was considered to be a minimal irritant according to the modified version of the
system described by Kay and Calandra.
The test article did not meet the criteria for classification as irritant according to the Globally Harmonized System of Classification and Labelling of
Chemicals (GHS).
Reference
Table1
Rabbit number, sex , initial and final body weights |
7 Male (2..3 - 2.4 kg) |
8 Male (2.7 - 2.6 kg) |
9 Male (2.6- 2.6 kg) |
|||||||||||||||
Initial sting response = 2 |
Initial sting response = 2 |
Initial sting response = 2 |
||||||||||||||||
Time after treatment |
½ hr |
1 hr |
4 hrs |
24 hrs* |
48 hrs* |
72 hrs |
½ hr |
1 hr |
4 hrs |
24 hrs* |
48 hrs* |
72 hrs |
½ hr |
1 hr |
4 hrs |
24 hrs* |
48 hrs* |
72 hrs |
CORNEA |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
E = Degree of Opacity |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
F = Area of Opacity |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Score (E x F) x 5 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
IRIS |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
D = Reaction |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Score (D x 5) |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
CONJUNCTIVAE |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A = Redness |
1 |
1 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
1 |
1 |
1 |
0 |
0 |
0 |
B = Chemosis |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
0 |
0 |
C = Discharge |
1 |
1 |
1 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
0 |
0 |
2 |
2 |
1 |
0 |
0 |
0 |
Score (A + B + C) X 2 |
4 |
4 |
2 |
0 |
0 |
0 |
8 |
8 |
0 |
0 |
0 |
0 |
8 |
8 |
4 |
0 |
0 |
0 |
Total Score |
4 |
4 |
2 |
0 |
0 |
0 |
8 |
8 |
0 |
0 |
0 |
0 |
8 |
8 |
4 |
0 |
0 |
0 |
Key:
* Fluorescein applied to cornea
Table2
Individual total scores and group mean scores
Rabbit Number and Sex |
Individual total scores at: |
|||
1 hour |
24 hours |
48 hours |
72 hours |
|
7 Male |
4 |
0 |
0 |
0 |
8 Male |
8 |
0 |
0 |
0 |
9 Male |
8 |
0 |
0 |
0 |
Group Total |
20 |
0 |
0 |
0 |
Group Mean Score |
6.7 |
0 |
0 |
0 |
Table3
Interpretation of results according to GHS
Rabbit Number and Sex |
Observation Time |
Corneal Opacity |
Iridial Inflammation |
Conjunctival Redness |
Conjunctival Chemosis |
|
7 Male |
24 Hours |
0 |
0 |
0 |
0 |
|
48 Hours |
0 |
0 |
0 |
0 |
||
72 Hours |
0 |
0 |
0 |
0 |
||
Total |
0 |
0 |
0 |
0 |
||
Mean Score |
0 |
0 |
0 |
0 |
||
8 Male |
24 Hours |
0 |
0 |
0 |
0 |
|
48 Hours |
0 |
0 |
0 |
0 |
||
72 Hours |
0 |
0 |
0 |
0 |
||
Total |
0 |
0 |
0 |
0 |
||
Mean Score |
0 |
0 |
0 |
0 |
||
9 Male |
24 Hours |
0 |
0 |
0 |
0 |
|
48 Hours |
0 |
0 |
0 |
0 |
||
72 Hours |
0 |
0 |
0 |
0 |
||
Total |
0 |
0 |
0 |
0 |
||
Mean Score |
0 |
0 |
0 |
0 |
||
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A skin irritation/corrosion test on rabbits (OECD Testing Guideline 404; Covance [2012d]) and an eye irritation test on rabbits (OECD Testing Guideline 405; Covance [2012e]) were conducted with potassium allophonate to assess the potential irritation/corrosion effects. Under the test conditions, potassium allophonate was considered not irritating to skin and eyes according to GHS or the CLP Regulation (Regulation [EC] No. 1272/2008).
In addition, two in vitro skin irritation/corrosion tests (OECD Testing Guidelines 439 and 431; Covance [2012d]) and an in vitro ocular irritation/corrosion test (OECD Testing Guideline 437; Covance [2012e]), were conducted on potassium allophonate. Under the in vitro test conditions, potassium allophonate was not considered corrosive to the skin or eyes.
References:
Covance. 2012d. Potassium Allophonate: Assessment of Skin Irritation/Corrosion. Testing laboratory: Covance Laboratories Ltd Otley Road, Harrogate North Yorkshire HG3 1PY ENGLAND. Report no.: 8249559. Owner company: Kerr Fire Fighting Chemicals, Ashcroft Road, Knowsley Industrial Park, Kirkby, Liverpool L33 7TS. Report date: 2013-01-07.
Covance. 2012e. Potassium Allophonate: Assessment of Ocular Irritation. Testing laboratory: Covance Laboratories Ltd Otley Road, Harrogate North Yorkshire HG3 1PY ENGLAND. Report no.: 8249560. Owner company: Kerr Fire Fighting Chemicals, Ashcroft Road, Knowsley Industrial Park, Kirkby, Liverpool L33 7TS. Report date: 2013-01-07.
Justification for selection of skin irritation / corrosion endpoint:
Study performed under Good Laboratory Practices (GLP)/Organisation for Economic Co-operation and Development (OECD) testing guidelines.
Justification for selection of eye irritation endpoint:
Study performed under GLP/OECD guidelines.
Effects on skin irritation/corrosion: slightly irritating
Justification for classification or non-classification
In a GLP/OECD Testing Guideline 404 skin irritation study, slight erythema was observed in a single animal at 24 and 48 hours (score = 1 out of a maximum score of 4) and well-defined erythema was observed at 72 hours (score = 2). No erythema was observed in the other two animals at any observation and no edema was observed in any animal at any observation. All irritation was fully resolved by 15 days post-application. Therefore, since an erythema scored at 2 was only observed at 72 hours and in a single animal, potassium allophonate is not classified as a skin irritant according to GHS and the CLP regulation.
In a GLP/OECD eye irritation study, minimal to moderate conjunctival irritation was noted in all treated eyes 0.5 and 1 hour after instillation, with minimal conjunctival irritation persisting in two treated eyes 4 hours after instillation. No signs of irritation were observed at 24, 48 or 72 hour post-application. Therefore, since potassium allophonate does not meet the criteria for classification as irritant or corrosive according to GHS or the CLP Regulation (Regulation [EC] No. 1272/2008), potassium allophonate is not classified as an eye irritant.
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