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EC number: 280-445-7 | CAS number: 83411-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From August 4th to 12th, 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- GLP guideline study with some restrictions: no certificate of analysis and a too short observation period (7 days, whereas occular effects are still observed at the termination of the study by day 7), no data on the animal environmental conditions (Temperature, humidity...)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : no certificate of analysis, the observation period is too short (only 7 days, whereas scores are still observed by day 7), no data on the animal environmental conditions (Temperature, humidity...)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bis(2,4,4-trimethylpentyl)phosphinic acid
- EC Number:
- 280-445-7
- EC Name:
- Bis(2,4,4-trimethylpentyl)phosphinic acid
- Cas Number:
- 83411-71-6
- Molecular formula:
- C16H35O2P
- IUPAC Name:
- bis(2,4,4-trimethylpentyl)phosphinic acid
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Pine Acres Rabbitry, W. Brattleboro, VT
- Age at study initiation: 12 to 14 weeks
- Weight at study initiation: 2.3 to 2.9 kg
- Housing: no data
- Diet (e.g. ad libitum): Charles River Rabbit Formula, Lot #W2162
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To:no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): not applicable, as the test item is used as supplied (undiluted)ì - Duration of treatment / exposure:
- The eye was not rinsed after administration of test item up to the end of the study in 6 animals while the eye of the other 3 animals was rinsed 20 to 30 seconds after the instillation.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 9 males
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, 6 animals were not rinsed and 3 animals were rinsed. The washing was done with 20 ml of lukewarm distilled water for 1 min
- Time after start of exposure: 20 to 30 seconds after the instillation
SCORING SYSTEM: grading for irritation and injury were made at 24, 48 and 72h and at 4 and 7 days, using the standard scoring system of Draize.
TOOL USED TO ASSESS SCORE: no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Remarks:
- animal not rinsed
- Basis:
- other: 4 out of 6
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- other: 1 out of 6
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- other: 1 out of 6
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Remarks:
- not rinsed
- Basis:
- other: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- other: 1 out of 6
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- other: 2 out of 6
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- other: 2 out of 6
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- other: 1 out of 6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- other: 2 out of 6
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- other: 1 out of 6
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- other: 2 out of 6
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- other: 1 out of 6
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- Corneal opacity in all 6 unrrigated eyes, which subsided completely in all but 2 eyes by day 7.
No effect on the iris during the course of the study.
Hyperemia was observed in all 6 eyes by day 1, which subsided completely in 3 eyes by day 7.
All 6 eyes also displayed chemosis on day 1, which was not observed in 3 of the eyes by the termination of the study.
The discharge observed in all 6 unirrigated treated eyes on day 1 subsided completely by day 7 in 4 of the eyes.
The 3 eyes treated with the sample and irrigated displayed no corneal opacity or injury of the iris during the treatment and the 7 day observation period. Transient conjunctivae scores (max. 1) for redness and chemosis were observed within the first 3 days of the study for those animals. - Other effects:
- no other effects
Any other information on results incl. tables
Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test. Only the scores of unirrigated animals are detailed in this table.
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae |
Chemosis |
Max. score: 4 |
Max. score: 2 |
Max. score: 3 |
Max. score: 4 |
|
24 h |
0/0/0/0/1/2 |
No effect |
2/2/1/2/1/2 |
3/3/2/2/2/4 |
48 h |
1/1/1/1/2/2 |
No effect |
1/2/1/1/1/2 |
1/2/1/2/2/3 |
72 h |
1/1/1/1/2/2 |
No effect |
1/2/3/2/1/2 |
1/2/2/2/2/3 |
Average 24h, 48h, 72h |
0.7/0.7/0.7/0.7/1.7/2.0 |
No effect |
1.3/2.0/1.7/1.7/1.0/2.0 |
1.7/2.3/1.7/2.0/2.0/3.3 |
Reversibility*) |
c/c/n/n/c/c |
- |
c/c/n/n/c/n |
c/c/n/n/c/n |
Average time (day) for reversion |
4/7/-/-/7/7 |
- |
4/7/-/-/4/- |
7/7/-/-/7/- |
*) Reversibility: c. = completely reversible;n.c.= not completely reversible; n. = not reversible
Applicant's summary and conclusion
- Interpretation of results:
- other: classified as an eye irritant according to the CLP Regulation (EC) No.1272/2008
- Conclusions:
- Eye irritant based on the chemosis scores which are equal or higher than 2 in 4/6 animals.
- Executive summary:
In an eye irritation study performed similarly to the OECD No. 405 guideline and in compliance with the GLP, 0.1 ml of undiluted test material was instilled into the conjunctival sac of left eye of 9 Albino New Zealand Rabbits (male). After the instillation the substance was not remained for 6 animals while for the three others the treated eye was washed with water 20 to 30 seconds after the instillation. Animals were then observed for 7 days for eye edema and erythema of the conjunctive, corneal opacity and iris lesion. Eye irritation was assessed and scored according to the Draize scale at 24, 48 and 72 hrs after the instillation of the substance and then at days 4 and 7. The mean individual score were calculated within 3 scoring times (24, 48 and 72 hrs).
For the animals whose eye was not rinsed, the mean individual scores were 1.7/2.3/1.7/2.0/2.0/3.3 for chemosis, 1.3/2.0/1.7/1.7/1.0/2.0 for conjunctival erythema, and 0.7/0.7/0.7/0.7/1.7/2.0 for corneal opacity. All of these effects were not totally reversible within the termination of the study (7 days) in all animals. Indeed, cornea opacity was still observed by day 7 in 2 animals, redness and chemosis of the conjunctiva were still observed in 3 animals. However there is a tendency to reversibility. In addition, there was no effect on the iris of all unirrigated animals. For the animals, whose eye was washed after the instillation, slight and transient effects of the conjunctiva were observed within the first 3 days after the instillation.
Under the test conditions, the test substance is considered as an Eye irritant based on the chemosis scores which are equal or higher than 2 in 4/6 animals.
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