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EC number: 273-870-4 | CAS number: 69103-20-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-GLP study following a method equivalent to a recognised OECD guideline. Deviations to recognised guideline are noted.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Occlusive dressing smaller exposure area (2.5cm2), longer exposure period (24h) shorter observation period (48h)
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.41
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2-dimethyl-3-(3-methylpenta-2,4-dienyl)oxirane
- EC Number:
- 273-870-4
- EC Name:
- 2,2-dimethyl-3-(3-methylpenta-2,4-dienyl)oxirane
- Cas Number:
- 69103-20-4
- Molecular formula:
- C10H16O
- IUPAC Name:
- 2,2-dimethyl-3-(3-methylpenta-2,4-dienyl)oxirane
- Test material form:
- other: liquid
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Recognised animal supplier
- Age at study initiation: at least 8 weeks
- Weight at study initiation:
- Housing: housed 2/cage in suspended wire mesh cages (30" x 18" x 18")
- Diet: rabbit chow ad libitum
- Water: ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 21
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped / abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): neat (liquid) - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 2 males; 4 females (6 in total)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm2
- % coverage: Not reported. The fur was clipped from the backs and sides of the animals. The back to the left of the spinal column of all animals was abraded. The abrasions, extending the length of the exposure site, scratched the stratum corneum but did not reach the derma or produce bleeding. The back to the right of the spinal column remained intact.
- Type of wrap if used: Occlusive (gauze wrapped with imperivous material)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not reported
- Time after start of exposure: Not applicable.
SCORING SYSTEM: Draize-scoring system. The mean values (6 rabbits) for erythema/eschar and edema formation on intact and abraded skin at 24 and 72 hours (a total of 8 values) are added and divided by 4 to give the Primary lrritation score. By the criteria of this test, Primary lrritant means a substance which is not corrosive, but which results in an empirical score of 5 or more. References: 16 CFR 1500.41 and 16 CFR 1500.3.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 1.88
- Max. score:
- 8
- Reversibility:
- no data
- Irritant / corrosive response data:
- Very slight to well defined erythema and very slight edema was noted during the observation period.
Any other information on results incl. tables
Table 1. Skin reactions (using Draize scoring method)
Erythema & Eschar Formation | Hours | Rabbit number | Mean score | |||||
1 | 2 | 3 | 4 | 5 | 6 | |||
Intact skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.00 |
72 | 1 | 2 | 1 | 1 | 2 | 2 | 1.50 | |
Abraded skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.00 |
72 | 1 | 2 | 1 | 0 | 1 | 1 | 1.00 | |
Edema | ||||||||
Intact skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.00 |
72 | 0 | 1 | 0 | 0 | 1 | 1 | 0.50 | |
Abraded skin | 24 | 1 | 1 | 1 | 1 | 1 | 1 | 1.00 |
72 | 0 | 1 | 0 | 0 | 1 | 1 | 0.5 | |
Sum of mean scores | 7.50 | |||||||
Primary irritation index = sum of mean scores/4 | 1.88 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US FDA
- Conclusions:
- Under the conditions of this study the test substance is not considered to be irritating to the skin of New Zealand white rabbits.
- Executive summary:
The non-GLP study was completed under 16 CFR 1500.41 following a guideline similar to OECD 404, to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit. The test substance was evaluated in 6 New Zealand white rabbits. A dose of 0.5 ml test substance was applied to intact and abraded clipped dorsal skin site under a occlusive dressing for 24 hours. Skin observations were made 24 and 72 hours after patch removal. Very slight erythema and edema were noted at 24 hours in both intact and abraded skin. By 72 hours, very slight to well defined erythema and very slight edema were observed in both intact and abraded skin. The test material produced a mean primary irritation index (PII) of 1.88 and is considered to be non-irritating to skin.
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