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EC number: 221-742-3 | CAS number: 3218-36-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A Primary Irritation Index (P.I.I.) of 1.2 was obtained at both intact skin and abraded skin on the white rabbit by the test substance. The test substance is thus, classified as slightly irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP and guideline mentioned. Basic data are given in the study report summary.
- Principles of method if other than guideline:
- Method according: Draize J. h., Woodard G.C. and Calvery H. O., J. Pharmacol. Expt. Therapeut 82: 377 (1944)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- other: Japanese white rabbit (male)
- Type of coverage:
- not specified
- Preparation of test site:
- abraded
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data
- Observation period:
- No data
- Number of animals:
- 6
- Details on study design:
- SCORING SYSTEM: : Primary Irritation Index (P.I.I) of the chemical evaluated based on skin changes appearing at 24 hours and 72 hours after application.
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 hours and 72 hours after application
- Score:
- 1.2
- Reversibility:
- fully reversible within: 72 hours to 192 hours after application
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- A Primary Irritation Index (P.I.I.) of 1.2 was obtained at both intact skin and abraded skin on the white rabbit by the test substance. The test substance is thus, classified as slightly irritating.
- Executive summary:
A Primary Irritation Index (P.I.I.) of 1.2 was obtained at both intact skin and abraded skin on the white rabbit by the test substance. The test substance is thus, classified as slightly irritating. Every skin changes on the 6 rabbits return to normal during the 72 hours to 192 hours after application.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A Primary Irritation Index (P.I.I.) of 1.2 was obtained at both intact skin and abraded skin on the white rabbit by the test substance. However, every skin changes on the 6 rabbits return to normal only 72 hours to 192 hours after application. The available information is thus regarded as inconclusive for classification
Justification for selection of skin irritation / corrosion endpoint:
Available study report summary.
Effects on skin irritation/corrosion: slightly irritating
Justification for classification or non-classification
The results of the skin irritation are regarded as inconclusive for classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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