cis-4-tert-butylcyclohexyl acetate

Surface tension

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 2013-03-15 to 2013-03-19

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance ID is adequately specified with purity and isomers composition. Therefore full validation applies.

Reason / purpose for cross-reference:

read-across: supporting information

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Qualifier:

according to guideline

Guideline:

other: ISO 304-1985 (E)

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP Compliance Programme (inspected on 10 July 2012 / signed on 30 Nov. 2012)

Type of method:

OECD harmonised ring method

Specific details on test material used for the study:

Storage condition of test material: room temperature, in the dark.

Surface tension:

62.9 mN/m

Temp.:

20 °C

Remarks on result:

other: 90% saturation

Water (calibration)

Temperature = 20.0 - 20.4°C

Sample A: calibration factor = 1.003 (mean of 6 readings)

Sample B: calibration factor = 1.003 (mean of 6 readings)

Test item

Temperature = 20.0 - 20.4ºC

Sample A: 62.5 mN/m (mean of 5 readings) = 62.7 mN/m corrected

pH = 5.6

Sample B: 62.9 mN/m (mean of 5 readings)= 63.1 mN/m corrected

pH = 5.6

As each (corrected) surface tension value was within 0.5 mN/m of the mean (corrected) value, the mean (corrected) value was considered to be acceptable as the endpoint of the test.

Conclusions:

According to EU A5 criteria, as the result is above the threshold value of 60 mN/m, the substance is NOT considered to have surface-active potential under the experimental conditions.

Executive summary:

The surface tension of the test substance was measured under GLP according to OECD 115/EU A5 guidelines, ring method, at 90% of the saturation solubility (from 1 g/L dispersion).

Two replicates were performed at 20°C, and the mean of the consistent values was corrected with calibration factor from water.

The surface tension was measured as 62.9 mN/m, at 90% saturation and 20°C.

Reference 2

Endpoint:

surface tension

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Based on structural similarity (same isomers in a different ratio), no significant difference is anticipated between the mixture of isomers tested and the dossier monoconstituent substance. Based on the chemical structure, the trans-form is regarded to have more orientation potential, therefore also surface-active potential. The study result could therefore be considered as a worst-case for the target substance.
Further information is included in IUCLID Section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

reference to other study

Key result

Surface tension:

>= 62.9 mN/m

Temp.:

20 °C

Conc.:

3.7 mg/L

Conclusions:

(from analogue) According to EU A5 criteria, as the result is above the threshold value of 60 mN/m, the substance is NOT considered to have surface-active potential under the experimental conditions.

Executive summary:

The surface tension of the analogue test substance was measured under GLP according to OECD 115/EU A5 guidelines, ring method, at 90% of the saturation solubility (from a 1 g/L dispersion).

Two replicates were performed at 20°C, and the mean of the consistent values was corrected with calibration factor from water.

The surface tension was measured as 62.9 mN/m, at 90% saturation and 20°C.

A similar, or slightly higher, ST is anticipated for the target substance.

Description of key information

Surface tension expected >= 62.9 mN/m, at 90% saturation and 20°C (from analogue)

Since the result is above the threshold value of 60 mN/m, according to EU A5 criteria, the substance is NOT considered as surface-active under the experimental conditions.

Key value for chemical safety assessment

Surface tension:

62.9

in mN/m at 20°C and concentration in mg/L:

3.7

Additional information

No data is available on the substance itself. However, a fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available on an analogue (mixture of isomers). As the study is expected to be worst-case compared to the present dossier monoconstituent substance, it fits for purpose of assessment of surface-active potential, so the read-across is considered justified for a key study, and the result is retained as key data.