Registration Dossier
Registration Dossier
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EC number: 278-859-8 | CAS number: 78181-99-4
Endpoint summary
Administrative data
Description of key information
Additional information
Acutely harmful to aquatic life. The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
This aquatic toxicity assessment was based on the following data:
The toxicity of the test substance to fish was investigated in two guideline studies. In a study according to Japanese Industrial Standard JIS K 0102 - 1974 Item 55 "Acute toxicity by fishes", the LC50 (96h) to Oryzias latipes was determined to be ca. 20 mg/L, based on nominal test concentrations (BASF AG 1983). This result is supported by a study according to DIN 38412 L15 using Leuciscus idus as a test organism. The LC50 (96h) in this study was found to be approx. 22 mg/L based on nominal concentrations (BASF AG 1980). In this study a product instead of the pure substance was tested. Therefore, the LC50 -value of this study was corrected for the content of the test substance of 46.69%, resulting in a LC50 -value of 10.27 mg/L. The resulting LC50 -value calculated (arithmetic mean) from both studies was calculated to be 15.1 mg/L.Based on these data the test substance is considered to be acutely harmful to fish.
The EC50 (48h) value of the test substance on daphnids was measured to be 20.2 mg/L in a GLP guideline according to OECD 202 (BASF AG 50E0382/11X289, 2013).Therefore, the test substance is considered to be acutely harmful to aquatic invertebrates.
A GLP guideline study according to OECD 221 using Lemna gibba as a test organism was conducted (BASF SE 99E0382/11X594, 2013). This test was conducted instead of a study using algae because the test substance is a dyestuff which would influence the photosynthesis capacity of algae cells in the test solution. In this study, the ErC50 (7d) on the growth rate (dry weight of the plants) was determined to be 15 mg/L. The lowest ErC10 (7d) was determined to be 0.84 mg/L for the growth rate (based on the frond numbers of the plants). Both values refer to the geometric mean measured concentrations.Based on these data the test substance is considered to be harmful to aquatic plants.
The toxicity to microorganisms was tested in a GLP approach according to OECD guideline 209 using domestic non-adapted activated sludge as inoculum (BASF 08G0382/11G150, 2012). After an incubation period of 180 minutes the EC10 was found to be 65 mg/L while the EC50 was estimated to be 170 mg/L, both related to the nominal concentrations.Based on these data, the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
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