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EC number: 232-216-8 | CAS number: 7790-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was selected as the key study because the information provided for the hazard endpoint is sufficient for the purpose of classification and labelling and/or risk assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption of Sulfate Ions in the Rat Lung
- Author:
- Charles JM & Menzel DB
- Year:
- 1 975
- Bibliographic source:
- Res. Commun. Chem Pathol Pharmacol., 12(2}:389-396
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- 35S was instilled into the trachea of anesthetized rats, at various time points lungs were removed and assayed for 35S radioactivity
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium sulphate
- EC Number:
- 231-820-9
- EC Name:
- Sodium sulphate
- Cas Number:
- 7757-82-6
- IUPAC Name:
- disodium sulfate
- Details on test material:
- - Purity: not reported
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 35S-sulfate ions
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-200 g
Administration / exposure
- Route of administration:
- intratracheal
- Vehicle:
- other: isotonic sucrose solution (300 mM, pH 7.4)
- Details on exposure:
- TYPE OF INHALATION EXPOSURE: other: instilled via a tracheal cannula into anesthetized animals
EXPOSURE PROCEDURE
Sprague Dawley rats, weighing 150-200 g, were anesthetized with pentobarbital. After the animal was secured on its back to a board, the trachea was isolated and 2 cm of a 5 cm long plastic cannula (PE 240) was inserted into the trachea through a transverse incision to a point approximately
0.5 cm above the bifurcation of the trachea. The mounting board was placed in an upright position. One tenth millilitre of an isotonic sucrose solution (300 mM, pH 7.4) containing either 0.01, 0.10, or 1.00 mM 35S-Na2S04 (specific activity-0.65 µCi/mmole), was injected into the lungs via the trachea cannula through a 1.5 inch 22 gauge needle attached to a 100 µL syringe. The solution was injected over a 1 to 2 second interval. - Duration and frequency of treatment / exposure:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.01, 0.10, or 1.00 mM
- No. of animals per sex per dose / concentration:
- 0.01 mM - 11 rats
0.10 mM - 3 rats
1.00 mM - 3 rats - Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: lung
- Time and frequency of sampling: 15, 30, 60 and 120 minutes after dosing
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- Amount of Na2S04 absorbed was proportional to initial concentration administered. Results suggested absorption occurred by nonsaturable process, such as simple diffusion. Half-life for sulphate absorption in the presence of sodium ions was 34.5 minutes.
Any other information on results incl. tables
Absorption of Sodium 35S-Sulphate from the Rat Lung |
|||
Concentration of Na2SO4 |
No. of Animals |
30 min. Absorption % dose |
Sulphate Ion Amount µg |
0.01 |
11 |
43.2 |
0.41 |
0.1 |
3 |
42.0 |
4.03 |
1.00 |
3 |
47.4 |
45.50 |
Applicant's summary and conclusion
- Conclusions:
- This study and the conclusions which are drawn from it fulfil the quality criteria (validity, reliability, repeatability).
A half-life of 34.5 minutes was observed. - Executive summary:
To investigate the absorption of 35S-sulphate ions from the rat lung in the presence of sodium ions, 0.1 mL of isotonic sucrose solution containing the salt was instilled via a tracheal cannula into anesthetized animals. After various times the lungs were removed and assayed for 35S-radioactivity. Sulphate ion absorption was found to be nonsaturable and proportional to the concentration of sulphate ion, with a t1/2 = 34.5 minutes.
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