Registration Dossier
Registration Dossier
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EC number: 233-953-8 | CAS number: 10466-65-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not given
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Published paper with little experimental detail. But data appears to be scientifically acceptable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Pharmacology and toxicology of potassium perrhenate and rhenium trichloride
- Author:
- Haley T.J. and Cartwright F.D.
- Year:
- 1 968
- Bibliographic source:
- Journal of Pharmaceutical Sciences Vol 57 (No. 2), 321-323
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Guideline:
- other: Draize J.H. et al. (1944). J. Pharmacol. Exptl. Therap. 82, 377
- Principles of method if other than guideline:
- The method of Draize et al. (1944) was used to study skin irritation in rabbits. 0.5 g of material applied to the skin of six animals and assessed for irritation.
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium perrhenate
- EC Number:
- 233-953-8
- EC Name:
- Potassium perrhenate
- Cas Number:
- 10466-65-6
- Molecular formula:
- K.O4Re
- IUPAC Name:
- Potassium oxido(trioxo)rhenium
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material (as cited in study report): Potassium perrhenate
- Physical state: Crystalline solid
- Analytical purity: Minimum 99.9%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- other: not stated, but presumably covered
- Preparation of test site:
- other: abraded and unabraded
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 g - Duration of treatment / exposure:
- Presumably 24 hours
- Observation period:
- Presumably 72 hours
- Number of animals:
- six
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Presumably based on Draize scores
- Conclusions:
- Potassium perrhenate was described as having no effect when applied to abraded or unabraded rabbit skin.
- Executive summary:
A brief published paper describes a skin irritation study in rabbits using the method of Draize et al. (1944). Potassium perrhenate (0.5 g) was applied (presumably as a covered patch) to the intact and abraded skin of six animals, presumably for 24 hours. No evidence of skin irritation was reported during an observation period of (presumably) 72 hours.
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