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Diss Factsheets
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EC number: 200-853-0 | CAS number: 75-24-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No information available.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no adverse effect observed
Additional information
Trimethylaluminium is classified as Pyr. Liquid 1, Water React. Flam. Gas 1 and Skin Corr. 1B. Therefore, the substance ignites upon exposure to air, reacts violently with water and causes severe burns to the skin and eyes. Consequently, it is not technically feasible to conduct toxicological studies with this substance.
Trimethylaluminium reacts spontaneously with water to produce aluminium hydroxide and methane or methanol and reacts spontaneously with air; the products of complete combustion being aluminium oxide, carbon dioxide and water. Therefore, the toxicological effects of aluminium oxide and aluminium hydroxide need to be considered when evaluating the effects of long-term exposure to trimethylaluminium.
Aluminium oxide and aluminium hydroxide are not classified for human health effects. These substances are of low acute oral toxicity with a very low oral bioavailability. Due to their insolubility in water, it is predicted that aluminium oxide and aluminium hydroxide will not be absorbed through the skin. Following inhalation exposure to aluminium oxide and aluminium hydroxide, the available data indicate that transfer of aluminium to the systemic circulation is low. There is no conclusive evidence that exposure to aluminium oxide or aluminium hydroxide leads to skin, eye or respiratory irritation effects. These aluminium salts also appear to have low sensitising potential. There are also no data to suggest that aluminium oxide and aluminium hydroxide are mutagenic or carcinogenic or that they have adverse reproductive/developmental effects.
Short description of key information:
Trimethylaluminium is classified as Pyr. Liquid 1, Water React. Flam. Gas 1 and Skin Corr. 1B. Therefore, the substance ignites upon exposure to air, reacts violently with water and causes severe burns to the skin and eyes. Consequently, it is not technically feasible to conduct toxicological studies with this substance.
Effects on developmental toxicity
Description of key information
Trimethylaluminium is classified as Pyr. Liquid 1, Water React. Flam. Gas 1 and Skin Corr. 1B. Therefore, the substance ignites upon exposure to air, reacts violently with water and causes severe burns to the skin and eyes. Consequently, it is not technically feasible to conduct toxicological studies with this substance.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
See Discussion under effects on fertility.
Toxicity to reproduction: other studies
Description of key information
No information available.
Justification for classification or non-classification
The substance is not classified for reproductive/developmental toxicity as it rapidly converts to aluminium oxide or aluminium hydroxide; both these substances are not classified.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.