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Diss Factsheets
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EC number: 223-342-4 | CAS number: 3845-76-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Although the study has been conducted according to GLP guidelines, no final report was drafted. As the data summary lacks detail on: identity/composition of test material, materials and methods which makes it difficult to interpret the available data and to reproduce the study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no details on the test method protocol followed were included in the report. Although the information is limited, it appears that the test procedure is in line with the HET-CAM test method protocol recommended by ICCVAM in 2006.
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-[3-(dimethylamino)propyl]acrylamide
- EC Number:
- 223-342-4
- EC Name:
- N-[3-(dimethylamino)propyl]acrylamide
- Cas Number:
- 3845-76-9
- Molecular formula:
- C8 H16 N2 O
- IUPAC Name:
- N‐[3‐(dimethylamino)propyl]prop‐2‐enamide
- Details on test material:
- In the study report no information is provided about the exact composition of the material tested. However, the DIMAPA test sample was taken at the end of the production process at "Ringleitung P10" which is the same sampling point as used for substance analytical identification.
Constituent 1
Test animals / tissue source
- Species:
- other: in vitro: Hen's Egg Test Chorioallantoic Membrane (HET-CAM)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 200 µl
- Observation period (in vivo):
- 0.5 min
- Number of animals or in vitro replicates:
- Chorioallantoic Membranes of 4 different eggs
Results and discussion
In vitro
Results
- Irritation parameter:
- other: HET-CAM score range
- Run / experiment:
- Mean
- Value:
- 12
- Remarks on result:
- other: Time point: 0.5 min; Max score: 21
- Other effects / acceptance of results:
- Irritant/corrosive response data: 12/21
Any other information on results incl. tables
Lysis | hemorrhage | coagulation | |||||||
egg # | 0.5' | 2' | 5' | 0.5' | 2' | 5' | 0.5' | 2' | 5' |
1 | 5 | - | - | 7 | - | - | - | - | - |
2 | 5 | - | - | 7 | - | - | - | - | - |
3 | 5 | - | - | 7 | - | - | - | - | - |
4 | 5 | - | - | 7 | - | - | - | - | - |
total | 20 | - | - | 28 | - | - | - | - | - |
Applicant's summary and conclusion
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Severe eye irritation
- Executive summary:
A HET-CAM study was performed on 4 chicken embryos (10d, 50-60 g eggs). Based on Lysis and Hemorrhage an avarage total score of 12/21 was observed which corresponds to "severely irritating to eyes".
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