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Diss Factsheets
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EC number: 915-657-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 40 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Overall assessment factor (AF):
- 50
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Most sensitive endpoint:
- skin irritation/corrosion
Workers - Hazard for the eyes
Additional information - workers
The basic dose descriptor for dermal short-term (acute) exposure was taken from an acute dermal toxicity study with the closely related substance Resin 835 A (Reaction mass of Rosin, hydrogenated and [1R-(1a,4aß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid)in rats and an LD50 >2000 mg per kg body weight.
Basic dose descriptorforlong-term exposure: In an oral repeated dose toxicity study (gavage) with the closely related substance Resin 835 A in the rat the NOAEL was 316 mg per kg body weight for males and females. 316 mg/kg body weight is taken as the basic dose descriptor for long-term exposure.
No DNELs are derived for acute or long-term exposure via inhalation, as exposure via inhalation is not likely: The vapour pressure Is very low (in the range of 10E-11 Pa at 25 °C).
All references are made to the"Guidance on information requirements and chemical safety assessment, Chapter R.8: Characterisation of dose [concentration]-response for human health"
The assessment factors (AF) used are given in the following order:
Interspecies metabolic rate for the conversion of the results from rat to human: 4 (dermal, oral)
- Interspecies remaining differences: 2.5
- Intraspecies: 5
- Factor to cover the
ratio LD50/NOEL: 1
or to extrapolate from sub-chronic to chronic exposure: 2
- Dose response reliability: 1
- Quality of whole database: 1
as inRefTable R.8-6.
Acute – short-term exposure, systemic effects:
Dermal
Dose descriptor starting point:
LD50dermal,acute >2000 mg/kg bw.
Overall AF= 4*2.5*5*1*1*1 = 50.
As no toxic signs were noted at the LD50,dermal the LD50,dermal is considered to be also the NOAEL,dermal. A factor of 1 is therefore applied to cover the ratio LD50/NOAEL.
Long-term exposure, systemic effects:
Dermal
Dose descriptor starting point:
NOELdermal = NOELoral,90d = 316 mg/kg bw.
The dermal absorption is considered to be generally lower as the oral absorption. As a worst case it is therefore assumed that the NOELdermal = NOELoral.
Overall AF= 4*2.5*5*2*1*1 = 100.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.35 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
DNEL related information
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 20 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Overall assessment factor (AF):
- 100
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Most sensitive endpoint:
- skin irritation/corrosion
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
- Most sensitive endpoint:
- skin irritation/corrosion
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.35 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
DNEL related information
- Overall assessment factor (AF):
- 600
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.3 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Overall assessment factor (AF):
- 300
- Modified dose descriptor starting point:
- LOAEL
General Population - Hazard for the eyes
Additional information - General Population
The basic dose descriptor for dermal short-term (acute) exposure was taken from an acute dermal toxicity study with the closely related substance Resin 835 A (Reaction mass of Rosin, hydrogenated and [1R-(1a,4aß,10aa)]-1,2,3,4,4a,9,10,10a-octahydro-7-isopropyl-1,4a-dimethylphenanthren-1-carboxylic acid)in rats and an LD50 >2000 mg per kg body weight.
The basic dose descriptor for oral short-term (acute) exposure was taken from an acute oral toxicity study with the closely related substance Dresinate 835 A (sodium salt) in rats and an LD50 >2000 mg per kg body weight. The LD0 was 1600 mg/kg body weight, signs of toxicity were observed also at 1600 mg/kg bw.
Basic dose descriptor for long-term exposure: In an oral repeated dose toxicity study (gavage) wirh Resin 835 A in the rat the NOAEL was 316 mg per kg body weight for males and females. In a reproduction/developmental toxicity screening test with the closely related substance rosin no effects on fertility and reproduction were seen at 208 to 352 mg per kg body weight. The NOAEL for the parental generation was between 71 and 109 mg per kg body weight and only marginal effects were seen at 208 to 352 mg per kg body weight in this study. A NOAEL of 208 mg per kg body weight is therefore taken as the basic dose descriptor.
No DNELs are derived for acute or long-term exposure via inhalation, as exposure via inhalation is not likely: The vapour pressure Is very low (in the range of 10E-11 Pa at 25 °C).
All references are made to the"Guidance on information requirements and chemical safety assessment, Chapter R.8: Characterisation of dose [concentration]-response for human health"
The assessment factors (AF) used are given in the following order:
Interspecies metabolic rate for the conversion of the results from rat to human: 4 (dermal, oral) or 1 (for inhalation)
- Interspecies remaining differences: 2.5
- Intraspecies: 10
- Factor to cover the
ratio LD50/NOEL: 1 or 3
or to extrapolate from the sub-acute to chronic exposure: 6
- Dose response reliability: 1
- Quality of whole database: 1
as inRefTable R.8-6.
Acute – short-term exposure, systemic effects:
Dermal
Dose descriptor starting point:
LD50dermal,acute >2000 mg/kg bw.
Overall AF= 4*2.5*10*1*1*1 = 100.
As no toxic signs were noted at the LD50,dermal the LD50,dermal is considered to be also the NOAEL,dermal. A factor of 1 is therefore applied to cover the ratio LD50/NOAEL.
Oral
Dose descriptor starting point:
LD0oral,acute 1600 mg/kg bw.
Overall AF= 4*2.5*10*3*1*1 = 300.
As signs of toxicity were noted at the LD0,oral a factor of 3 is applied to cover the ratio LD50/NOAEL.
Long-term exposure, systemic effects:
Dermal
Dose descriptor starting point:
NOELdermal = NOELreproduction/developmental toxicity screening test,oral = 208 mg/kg bw.
The dermal absorption is considered to be generally lower as the oral absorption. As a worst case it is therefore assumed that the NOELdermal = NOELoral.
Overall AF= 4*2.5*10*6*1*1 = 600.
Oral
NOELoral = NOELreproduction/developmental toxicity screening test,oral = 208 mg/kg bw.
Overall AF= 4*2.5*10*6*1*1 = 600.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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