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Diss Factsheets
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EC number: 204-817-5 | CAS number: 126-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral NOAEL of 7.5 mg/kg bw/day with gender specific differences in the rat (OECD 422 and 408)
Oral NOAEL of 6 mg/kg bw/day in male and female mice (OECD 422)
Inhalation NOAEL of 19.3-52.6 ppm in male and female rats (published data)
Inhalation NOAEL of 3.2-8.8 ppm in male dogs (published data)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 7.5 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEC
- 53.8 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Additional information
ORAL TOXICITY
The key study (Ghanayem, 2000), conducted over 90 days, reports gender specific differences in the rat with a NOAEL of 7.5 mg/kg bw/day. Supporting studies confirm these data for the rat (Sunaga, 2001) and report a NOAEL of 6 mg/kg bw/day in the mouse (Ghanayem, 2000). Supporting studies also show an absence of abnormal change in electrophysical parameters in spite of obvious general toxicity (Gagnaire et al, 1998) and demonstrate impaired intracellular oxygen utilisation due to liberation of cyanide (Vasanthakumani et al, 1998).
INHALATION TOXICITY
The key study (Pozzani 1968) reports that the NOAEL for the rat is between 19.3 and 52.6 ppm.
Justification for classification or non-classification
As in the case of acute cyanide toxicity, the central nervous system is clearly among the most sensitive tissues because of high oxygen demand. However, in principle, there is no difference between short-term and long-term effects, which have the same toxicological basis. Repeated exposure only increases the the likelihood that the threshold for irreversible damage is exceeded on a particular treatment day as a result of normal variation in dose. From a mechanistic point of view, the central nervous system effects in repeated dose studies are due to single exposure events and are not cumulative. It is therefore considered sufficient to classify methacrylonitrile as toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed under the terms of EU Directive 67/548/EEC and STOT Single Exp. 1 under GHS as implemented by Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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