Registration Dossier
Registration Dossier
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EC number: 253-506-0 | CAS number: 37439-34-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic toxicity of Dursban and its metabolite 3,5,6-trichloro-2-pyridinol in chickens
- Author:
- Satoru Miyazaki; George C. Hodgson
- Year:
- 1 972
- Bibliographic source:
- Toxicology and applied pharmacology 23
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Test material was administered by gavage to Cockerels. To compare toxicity Aedes aegypti larave were placed in a beaker and treated with test material. After 24 h mortality rates were recorded and compared.
- GLP compliance:
- not specified
- Test type:
- other: acute tox by gavage on chickens, control on larvae: LD50 calculated by probit analysis
Test material
- Reference substance name:
- 3,5,6-trichloro-2-pyridinol sodium salt
- IUPAC Name:
- 3,5,6-trichloro-2-pyridinol sodium salt
- Details on test material:
- Purity of pyridinol-salt was tested by thin-layer chromatography.
Constituent 1
Test animals
- Species:
- hen
- Strain:
- other: white leghorn Hy-Line 934E
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled
- Doses:
- 2% solution
- No. of animals per sex per dose:
- 20 2 week old
- Control animals:
- other: aedes aegypti larvae
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 1 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: classification not possible from the reasults given in the publication
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Classification not possible from the results given in the publication. However, given the high dosis compared to the low mortality, the material may be considered harmful.
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