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Diss Factsheets
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EC number: 441-420-8 | CAS number: 113889-23-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity (according to OECD423, GLP): LD50 > 5000 mg/kg bw
Acute dermal toxicity (according to OECD402, GLP): LD50 > 2000 mg/kg bw
Acute inhalation toxicity (using route to route calculation): LD50 > 13000 mg/m3
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The selected study is the key (and only) study and is adequate to cover this endpoint.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute toxicity via oral route: In an acute oral toxicity study (according to the acute toxic class method), three males and three females were administered 2000 mg/kg bw Cyclobutanate by gavage. No mortality was observed. Clinical observations were hunched posture in all females, ataxia and lethargy in one female. No signs of systemic toxicity were noted in males. No abnormalities were noted at necropsy. The acute oral median lethal dose was estimated at >5000 mg/kg bw based on the scheme of the updated OECD TG 423 (2001).
Acute toxicity via dermal route: An acute dermal toxicity test (limit test) was performed with Cyclobutanate as testing material. The test was performed according to OECD guideline 402 (Acute dermal toxicity) in a group of 10 rats (5 males, 5 females). The rats were dermally exposed to the substance at 2000 mg/kg bw for 24 hours. The substance was applied to a shorn skin (approximately 10% of body surface) using a graduated syringe. A piece of surgical gauze was placed over the treatment area and semi-occluded with a piece of self-adhesive bandage. No mortality was observed in the 14 days period after exposure. No signs of systemic toxicity were observed during clinical observation. No signs of dermal irritation were noted in male animals. Very slight erythema was noted in all female animals one to three days after dosing. No abnormalities were noted at necropsy. Body weight of all animals increased during study. The acute dermal median lethal dose (LD50) of the test material in the Sprague-Dawley strain rat, was found to be >2000 mg/kg bw.
Acute toxicity via vapour: The oral LD50 of >5000 mg/kg bw can be roughly converted into mg/m3 with the following equation: 1 mg/kg bw = 0.0052 mg/l/4h (ECHA guidance on CLP, 2017). For conservative reasons the inhalation absorption is set at 100% and orally at 50%. This results in > 13000 mg/m3. With a maximum SVC of 1013 mg/m3 the inhalation LC50 cannot be reached.
Justification for classification or non-classification
Based on the oral LD50 > 5000 and the dermal LD50 > 2000 mg/kg bw in rats and the calculated inhalation LC50 > 13000 mg/m3, Cyclobutanate does not have to be classified as acute toxic, in accordance with EU CLP (EC no 1272/2008 and its amendments).
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