Registration Dossier
Registration Dossier
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EC number: 213-986-4 | CAS number: 1071-22-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to microorganisms: 3hr ASRI EC50 >100 mg/l (OECD 209) for read-across substance 3 -(triethoxysilyl)propiononitrile
Key value for chemical safety assessment
Additional information
No reliable data are available for the toxicity to microorganisms of the submision substance 3 -(trichlorosilyl)propiononitrile.
3 -(trichlorosilyl)propiononitrile hydrolyses very rapidly to 3 -(trihydroxylsilyl)propiononitrile.
The other hydrolysis product is HCl.Effects of hydrogen chloride on microorganisms are limited to those that result from changes to pH in unbuffered media.
A toxicity to microorganisms study is available for the related substance 3 -(triethoxysilyl)propiononitrile.
It is considered appropriate to read across the toxicity to microorganisms result for 3 -(triethoxysilyl)propiononitrile because, though it does not hydrolyse significantly in the timescale of the ASRI test (t1/2 6.5 hrs, pH7, measured), it does indicate that the propiononitrile group does not exhibit toxicity to microorganisms. This read-across, indicating no evidence of toxicity to microorganisms, is supported by an overall review of the toxicity to microorganisms of the organosilane substances category as a whole.(Data gap filling report for ready biodegradability of silicon-dominated substances PFA.151.004.022A and
Data gap filling report for ready biodegradability of carbon-dominated substances PFA.151.004.022B)
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