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EC number: 282-810-6 | CAS number: 84434-11-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no studies available for the determination of toxicokinetics or dermal absorption.
Ehtylphenyl (2,4,6 -trimethylbenzoyl) phophinate is a liquid with a molecular weight of 316 g/mol and a very low vapour pressure of 2x10e-4Pa at 20 °C. In agreement with its logPow of 2.9, only 35mg can be dissolved in one liter of water. Due to its low vapour pressure, exposure to vapor is unlikely. The combination of a molecular weight below 500g/mol and moderate lipophilicity (logPoW between 1 and 4) favor oral as well as dermal uptake. Though acute dermal and oral toxicity tests did not show signs of systemic toxicity, sensitization was observed, hinting to dermal uptake of at least small amounts. From the logPoW below 4 it is expected, that the substance does not bioaccumulate.
No mutagenicity or chromosomal aberration was observed, so no reactivity with macromolecules is expected prior to excretion.
Oral gavage over a period of 4 weeks did not reveal signs of systemic toxicity in male and female Wistar rats up to a dose level of 500 mg/kg bw/d. The oral administration of the test substance by gavage to male and female Wistar rats for 3 months caused test substance-related, adverse signs of systemic toxicity at a dose level of 500 mg/kg bw/d taking impaired body weight development, as well as altered clinical pathology parameters and pathology findings into account. Therefore, under the conditions of the present study the NOAEL was 100 mg/kg bw/d for male and female Wistar rats.
Under the conditions of the prenatal developmental toxicity study, the oral administration of the registered substance to pregnant Wistar rats from implantation to one day prior to the expected day of parturition (GD 6-19) caused adverse effects at the highest tested dose of 300 mg/kg bw/d. Maternal toxicity was determined by a normocytic-normochromic, anemic situation. Increases in absolute and relative liver weights indicated a treatment-related adaptive change. In conclusion, the no observed adverse effect level (NOAEL) for maternal toxicity is 100 mg/kg bw/d. In fetuses, three skeletal variations affecting the skull, ribs and sternebrae were assessed as treatment-related but not as adverse. These minor and reversible effects indicate a developmental delay which is reversible. Thus, the no observed adverse effect level (NOAEL) for prenatal developmental toxicity is 300 mg/kg bw/d while the no observed effect level (NOEL) for prenatal developmental toxicity is 100 mg/kg bw/d.
The results of the studies conducted with repeat exposure indicate that the registered substance is being absorbed, and at higher doses is having a toxicological effect on the model used. The NOAEL for repeat exposure toxicity is set at 100 mg/kg bw/day which is outside the guidance value range for specific target organ toxicity - repeat exposure (oral - rat) Category 2. As such the toxicological effect seen is considered to be insufficient for classification in accordance with the EU Classification, Labelling, and Packaging (CLP) regulation (1272/2008).
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