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Diss Factsheets
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EC number: 227-578-9 | CAS number: 5895-45-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
For the purposes of human risk assessment, oral absorption of dipraseodymium tricarbonate is estimated at 50%, inhalation absorption is estimated at 100% and dermal absorption is estimated at 25%.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 25
- Absorption rate - inhalation (%):
- 100
Additional information
Introduction
The substance is a green powder. No experimental studies with animals or humans on absorption, metabolism, distribution, or elimination are available for the substance. However, information is available from existing toxicology studies to infer potential toxicokinetic properties. Systemic availability of dipraseodymium tricarbonate depends on its ability to be absorbed across body surfaces. A major factor affecting this process is water solubility (4.39 mg/L, “slightly” soluble), The solubility increases as the pH decreases. The material decomposes at 420ºC. The substance has a molecular weight of 461.8 g/mol.
Absorption
Oral absorption
Non-adverse effects were observed in a GLP-compliant OECD 422 repeat dose toxicology study conducted up to 1000 mg/kg bw/day (read-across from praseodymium oxide) suggesting that there may be some absorption following oral exposures. The NOAEL was considered to be 1000 mg/kg/day (the top dose tested) for parental, reproductive and foetal toxicity. The acute oral LD50 was estimated to be greater than 2000 mg/kg bw in a GLP-compliant OECD 420 oral gavage study, with no clinical signs no effect on body weight gain and, no gross abnormalities upon necropsy. It can be concluded from the study data that significant absorption via the oral route is unlikely, although in the absence of other information, and unknown effect of the acidity of the stomach, 50% bioavailability is assumed.
Dermal absorption
No studies investigating the absorption through the skin were available. A skin sensitisation study was negative, from which nothing can be inferred. Given its low solubility and that it is a solid, dermal absorption is expected to be minimal. For the purposes of DNEL setting however, estimation of mammalian dermal absorption is made in accordance with principles adopted EFSA guidance on estimating dermal absorption of pesticide active substances (EFSA, 2012). On this basis, dermal absorption is estimated at 25% for undiluted material.
Inhalation absorption
In an acute inhalation study, nose-only exposure for 4 hours, concentrations as high as 5.25 mg/L air did not cause any mortality. Limited clinical signs were observed in few animals during exposure and up to the day following exposure, although these were non-specific and common to inhalation of insoluble powders. Macroscopic examination at termination, 14 days after the 4-hrs exposure revealed no macroscopic abnormalities. It can be concluded from the study data that significant absorption via the inhalation route is unlikely. However in the absence of any quantitative data, absorption of material that makes it into the alveoli is considered to be 100%.
Distribution and metabolism
No information is available to describe the distribution and metabolism.
Conclusion
For the purposes of human risk assessment, oral absorption of dipraseodymium tricarbonate is estimated at 50%, inhalation absorption is estimated at 100% and dermal absorption is estimated at 25%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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