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Diss Factsheets
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EC number: 267-023-8 | CAS number: 67762-55-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 25
- Absorption rate - inhalation (%):
- 100
Additional information
In accordance with point 8.8.1 of column 1 (Standard Information Required), Annex VIII of REACH (Regulation EC No. 1907/2006), assessment of the toxicokinetic behaviour of the substance is performed to the extent that can be derived from the relevant available information. A toxicokinetic assessment was performed based on the available physical-chemical data and toxicological information available. Further testing for the assessment of toxicokinetic behaviour is omitted on this basis.
Introduction
The substance is a brown liquid and is a UVCB organic substance. No experimental studies of the absorption, metabolism, distribution, or elimination of Alkenes, C15-18 α-, sulfurized in mammals are available. However toxicology studies on the substance are available and these data are used to infer, where possible, the potential toxicokinetic profile of the substance.
Physicochemical properties
Systemic availability of the substance depends on its ability to be absorbed across body surfaces. Factors that affect this process include water solubility, lipophilicity (measured by the partition coefficient, Kow), degree of ionization (the dissociation constant, pKa), and molecular size. The components of the substance have molecular weights ranging in the region of 176-602 g/mol, with a mean molecular weight of 520 g/mol. The substance is virtually insoluble in water (≤5.6 mg/L in 20 ºC). The dissociation constant was not technically feasible. The log Kow was >9.4. With respect to the boiling point, the test material lost a volatile fraction from approximately 229 °C with decomposition as heating continued. The vapour pressure at 25 ºC was 0.052 Pa.
Absorption
Oral absorption
The acute oral LD50was greater than 2000 mg/kg bw in an acute oral gavage toxicity study (OECD 423), with no treatment related clinical signs and no effect on body weight were observed. In addition, no treatment related gross abnormalities were observed at necropsy. In an OECD 422 repeat-dose/reproductive toxicity study with there was a complete absence of any indication of toxicity up to the limit dose of 1000 mg/kg.
Nothing can be inferred about the nature of oral absorption from these studies, although given the very high log Pow, one interpretation might reasonably be that this is a consequence of no absorption across the GIT.
In the absence of useful qualitative or quantitative information, 50% bioavailability following oral administration is assumed for the purposes of human risk assessment.
Dermal absorption
No adverse effects were observed in an acute dermal toxicity study (OECD 402, limit dose test). Eye irritation, skin irritation and skin sensitisation studies gave no signs that the test material reacted chemically with living layers of the skin or eye. Nothing can be inferred about the dermal penetration properties of the substance from these studies. From guidance, components with MW less than 400 are expected to cross this skin barrier fairly easily but this may be mitigated to a large extent by the extremely high Kow value. As with absorption across the GIT, dermal absorption might also reasonably be considered zero.
For the purposes of risk assessment however, estimation of mammalian dermal absorption is made in accordance with principles adopted by the EFSA guidance on estimating dermal absorption of pesticide active substances (EFSA, 2012). On this basis, dermal absorption is estimated at 25% for undiluted substance.
Inhalation absorption
In the absence of any qualitative or quantitative data, absorption of the substance is considered to be 100%.
Distribution, Metabolism and Elimination
In an OECD 301B ready biodegradability study, a biodegradation value of 51% was obtained for the test material after 28 days. No further information is available to describe the distribution, metabolism or elimination of any substance that might be absorbed, although degradation would likely occur in the peroxisomes.
Conclusion
For the purposes of human risk assessment oral absorption of the substance is estimated at 50%, inhalation absorption is estimated at 100% and dermal absorption is estimated at 25%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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